| 摘要: |
| H7N9病毒是一种来自鸟类的禽流感病毒毒株基因重配的新型病毒。H7N9病毒的血凝素(HA)和神经氨酸酶(NA)在种间传播、病毒复制和致病性等方面起着重要作用。新型H7N9病毒最显著的特征之一是在家禽中无明显致病性,却能感染人类并引起较高的病死率。H7亚型禽流感病毒可有不同的NA亚型,具有较强的兼容性,已引起多次人类的感染事件。可以预见这种影响还将会持续并引起严重的公共卫生问题,必须对此加以高度关注。健全的防控网络的建立有助于最大限度地减少禽流感对人类健康和生命的危害。 |
| 关键词: H7N9亚型流感病毒A型 病毒特征 公共卫生 传染病控制 |
| DOI：10.3724/SP.J.1008.2013.00591 |
| 投稿时间：2013-05-05修订日期：2013-05-27 |
| 基金项目:上海市公共卫生重点学科建设项目(12GWZX0102). |
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| Novel avian influenza A H7N9 virus: viral feature and potential threat to human health |
| ZHANG Hong-wei* |
(Department of Epidemiology, Faculty of Tropical Medicine and Public Health, Second Military Medical University, Shanghai Key Laboratory of Medical Biodefense, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| H7N9 virus is a novel avian-origin virus. The hemagglutinin (HA) and neuraminidase (NA) of the virus play key roles in the interspecies transmission, viral replication and pathogenicity. One of significant characters of H7N9 is that it has no noticeable pathogenicity among poultry, but is highly pathogenic for human being and is associated with high mortality. H7 subtype avian virus can be compatible with different NA subtypes, and has caused many infection events in human being. It can be predicted that the influence of H7 subtype avian influenza A virus will persist and lead to serious public health problem, and therefore deserves more attention. Establishment of prevetion and control network can help to reduce the threat of H7N9 virus to human health. |
| Key words: H7N9 subtype influenza A virus viral feature public health communicable disease control |
