| 摘要: |
| MicroRNA(miRNA)是一类通过作用于靶基因mRNA发挥转录后基因调控活性的小分子非编码RNA,参与生物体内各种基本的生物学进程,它的异常表达与疾病的发生发展密切相关。近期的研究证实,肾脏缺血再灌注损伤(IRI)后多种miRNA异常表达,可能参与了肾脏IRI过程的调控。miRNA可调控内皮细胞、树突状细胞和巨噬细胞中炎性介质的合成与分泌,从而影响肾脏IRI过程的炎症反应。同时,也有miRNA作用于凋亡与增殖相关基因,从而调控IRI时肾小管上皮细胞的凋亡与增殖。miRNA还可诱导内皮祖细胞的聚集,从而促进损伤肾组织的血管生成与修复。细胞外的研究显示,miRNA在血清和尿液中的即时变化可能反映了肾脏IRI的损伤程度。因此，miRNA可能会成为肾脏IRI的一种新的生物学标记物和潜在的治疗靶点。 |
| 关键词: 微RNAs 再灌注损伤 急性肾损伤 生物学标记 |
| DOI： |
| 投稿时间：2013-05-31修订日期：2013-08-26 |
| 基金项目:国家自然科学基金(81372038),上海市卫生局科研课题(2009115). |
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| Role of microRNAs in renal ischemia-reperfusion injury: an update |
| LI He-wen1,WANG Jia-feng2,YU Guang1* |
(1. Department of Nephrology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
2. Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| MicroRNAs (miRNAs) are a class of small non-coding RNA which exert post-transcriptional gene regulation activity by targeting messenger RNAs. miRNAs have been found involved in a great variety of fundamental biological processes, and deregulation of miRNAs is known to be closely related to morbidity. Recent studies have confirmed that several miRNAs were differentially expressed after renal ischemia-reperfusion injury (IRI), and some of them might be involved in IRI regulation. miRNAs can influence the expression of inflammatory mediators in endothelial cells, dendritic cells and macrophages,and thus regulate inflammatory response during renal IRI. miRNAs might also influence genes related to apoptosis and proliferation, and thus regulate apoptosis and proliferation of tubular epithelial cells. miRNAs could also induce accumulation of endothelial progenitor cells in renal tissue and facilitate angiogenesis and injury repair. Extracellular studies have also showed that instant change of some miRNAs in serum and urine might reflect the degree of renal IRI. Therefore, miRNAs might serve as new biomarkers as well as potential therapeutic targets for renal IRI. |
| Key words: microRNAs reperfusion injury acute kidney injury biological markers |
