| 摘要: |
| 目的 进一步了解KD患儿病程中血小变化规律，探讨血清TSP-1与血小板动态变化的关系及可能机制。方法 采用酶联免疫吸附法检测2011年9月1日至2012年12月31日我院住院治疗的32例KD患儿及30例对照组患儿血清TSP-1浓度、PLT及血小板相关参数并进行统计学分析。结果（1）急性期血清TSP-1浓度明显升高，随着病情变化，浓度逐渐降低；PLT急性期有升高趋势，亚急性期达到高峰；血小板活化程度于急性期最高，之后逐渐降低。（2）KD患儿病程中血清TSP-1与PLT无线性相关关系。结论（1）血清TSP-1浓度与血小板的活化程度变化趋势一致，可以作为评估血小板活化程度的一个指标，KD患儿急性期血小板活化最明显。（2）TSP-1对KD患儿血小板生成抑制作用有待进一步研究。 |
| 关键词: 川崎病 血小板 血小板敏感蛋白1 |
| DOI：10.3724/SP.J.1008.2014.00340 |
| 投稿时间：2013-06-29修订日期：2013-08-26 |
| 基金项目: |
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| Changes of serum thrombospondin-1 in children with Kawasaki disease |
| LIU Lu-qiong1,DONG Xiang-yu2* |
(1. Department of Pediatrics, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China;
2. Department of Pediatric Cardiovascular Diseases, Second Hospital of Lanzhou University, Lanzhou 730030, Gansu, China
*Corresponding author.) |
| Abstract: |
| Objective To observe the distribution of serum thrombospondin-1. platelet total and platelet parameters in children with Kawasaki disease and children in the control group, to explore deeply the law of changes of platelets，and relation between TSP-1 and changes of platelets, its potential mechanisms. Methods Serum TSP-1 were measured by Enzyme-linked immunosorbent assay, PLT and platelet parameters were measured by Automatic Hematology Analyzer in 32 cases of KD inpatients of pediatric department during September 1 st, 2011 and December 31st, 2012, 30 cases of children in similar ages in the control group were measured the same indicators during the same period，relative data were analyzed. Results (1) Serum TSP-1 was highest in acute phase and decreased little by little; PLT reached the peak in sub-acute phase; The activity of platelet reached the strongest level in acute children with KD and decreased then. (2) There was no correlation between the level of serum TSP-1 and PLT in acute, sub-acute and convalescent phase. Conclusions (1) The level of serum TSP-1 is related to the activity of the platelet, it can be used as an indicator to evaluate the extent to which the activity of platelet reaches. The activity of platelet reaches the strongest in acute children with KD.（2）Inhibition to thrombocytosis is unclear in children with KD, it needs more deep investigation. |
| Key words: Kawasaki disease blood platelets thrombospndin-1 |
