| 摘要: |
| 目的 比较组成成分相近而比表面积与孔径不同的介孔材料和微孔材料的止血性能和放热反应规律，为以介孔材料为载体研发新型急救止血剂奠定基础。方法 将15只雄性家猪随机分为3组（A组、B组、C组），分别建立猪股动脉致命性出血模型，A组应用介孔材料HW止血，B组应用微孔材料ZSM-5止血（阳性对照），C组应用标准纱布止血（阴性对照）。比较3组材料的止血性能以及放热反应对组织的影响。结果 A和B组止血时间分别为（49.50±3.27）s和（59.50±2.42）s（P<0.05），C组应用标准纱布止血失败；A、B、C各组局部最高温度分别为（42.0±1.58）、（46.4±1.14）和（36.8±0.84）℃，各组间差异均有统计学意义（P<0.05）；组织学检查发现A组应用介孔材料HW的放热反应对组织造成的损伤轻于B组微孔材料ZSM-5。结论 介孔材料HW比微孔材料ZSM-5具有更加快速的止血性能和更轻的放热反应，有望成为新一代急救止血剂研究载体。 |
| 关键词: 创伤和损伤 出血 止血材料 微孔材料 介孔材料 |
| DOI：10.3724/SP.J.1008.2014.00291 |
| 投稿时间：2013-07-17修订日期：2013-11-16 |
| 基金项目: |
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| Hemostatic efficacies of mesoporous materials HW and microporous materials ZSM-5：a comparative study |
| XU Da-yuan1,BI Hong-da1,CAI Guo-jun2,XING Xin1* |
(1. Department of Plastic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
2. Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| Objective To compare the hemostatic efficacies and exothermic reactions between mesoporous and microporous materials with similar components but different specific surface areas and pore sizes, so as to lay a foundation for developing new first-aid hemostat with mesoporous materials. Methods Totally 15 male pigs were made into femoral artery fatal hemorrhage models and were randomly divided into three average groups (group A, group B and group C). Their hemostatic efficacies and exothermic reactions on the tissues were compared between the three groups (group A was treated with hemostatic mesoporous material HW, group B with microporous material ZSM-5, and group C with standard gauze as control). Results The hemostatic time periods of group A and B were (49.50±3.27) s and (59.50±2.42) s, respectively (P<0.05); standard gauze in group C had failed hemostatic effect. The highest local temperature rose to (42.0± 1.58) ℃in group A, (46.4±1.14)℃ in group B, and (36.8±0.84)℃ in group C, with significant difference found between different groups (P<0.05). Histological test showed that the tissue damage caused by exothermic reaction of mesoporous material HW was slighter than that of microporous material ZSM-5. Conclusion Compared to mesoporous material HW, the microporous material ZSM-5 has more rapid hemostatic efficacies and slighter exothermic reaction, and ZSM-5 is a promising carrier for next generation first-aid hemostatic study. |
| Key words: wounds and injuries hemorrhage hemostatic materials microporous materials mesoporous materials |
