| 摘要: |
| 目的 探讨SALL4、Bmi-1和β-catenin在食管鳞状细胞癌组织中的表达及其临床意义。方法 采用免疫组化法检测70例正常食管黏膜、70例异型增生黏膜和123例食管鳞癌组织中SALL4、Bmi-1和β-catenin蛋白的表达水平，分析上述3种蛋白与食管鳞癌临床病理特征的关系。结果 正常食管黏膜组、异型增生黏膜组和食管鳞癌组中SALL4、Bmi-1蛋白的阳性表达率和β-catenin蛋白的异常表达率均逐渐升高，食管鳞癌组和异型增生黏膜组 SALL4、Bmi-1的阳性表达率、β-catenin蛋白的异常表达率均高于正常食管黏膜组（均P<0.01），食管鳞癌组Bmi-1阳性表达率和β-catenin蛋白的异常表达率均高于异型增生黏膜组（均P<0.01），而SALL4蛋白的阳性表达率在食管鳞癌组和异型增生黏膜组间的差异无统计学意义（P>0.05）。在异型增生黏膜组，Bmi-1蛋白的阳性表达率随异型增生程度的增高而升高（P<0.01）。123例食管鳞癌组中SALL4蛋白的表达与临床分期（P<0.05）、淋巴结转移（P<0.01）密切相关，Bmi-1和β-catenin蛋白的表达与浸润深度、分化程度和淋巴结转移相关（均P<0.05）。123例食管鳞癌组中SALL4、Bmi-1和β-catenin蛋白表达两两正相关（SALL4和Bmi-1：r=0.373，P<0.01；SALL4和β-catenin：r=0.214，P<0.05；Bmi-1和β-catenin：r=0.204，P<0.05）。结论 SALL4、Bmi-1和β-catenin可能参与食管鳞癌的发生、发展，并在食管鳞癌的浸润和转移中起一定作用；三者可能通过相应的信号转导通路相互联系。 |
| 关键词: 食管肿瘤 鳞状细胞癌 SALL4 Bmi-1 β-catenin |
| DOI：10.3724/SP.J.1008.2014.00406 |
| 投稿时间：2013-08-11修订日期：2014-01-24 |
| 基金项目: |
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| Expression of SALL4, Bmi-1 and β-catenin in esophageal squamous cell carcinoma and the related clinical significance |
| ZHANG Xin,GAO Yuan,XING Rong-ge,GUO Xiao-zhong,WANG Xiu-rong |
(Department of Pathology, the Central Hospital of Cangzhou, Hebei Medical University, Cangzhou 061000, Hebei, China
*Corresponding author.) |
| Abstract: |
| Objective To investigate the expression of SALL4, Bmi-1 and β-catenin in esophageal squamous cell carcinoma (ESCC) and the related clinical implications. Methods Immunohistochemical staining was used to detect the expression of SALL4, Bmi-1 and β-catenin in 70 normal esophageal mucosa specimens,70 dysplasia mucosa specimens and 123 ESCC specimens; and the relationship of their expression with the clinicopathological characteristics of ESCC was analyzed. Results The positive rates of SALL4, Bmi-1 and the aberrant rate of β-catenin expression gradually increased in order in normal esophageal mucosa, dysplasia mucosa and ESCC groups. The positive rates of SALL4, Bmi-1 and the aberrant rate of β-catenin expression in the dysplasia mucosa and ESCC groups were significantly higher than those in normal esophageal mucosa group (P<0.01); those in ESCC group was significantly higher than those in the dysplasia mucosa (P<0.01); and the positive rates of SALL4 were not significantly different between the dysplasia mucosa and ESCC groups (P>0.05). In the dysplasia mucosa group, the positive rate of Bmi-1 increased along with the degree of dysplasia (P<0.01). In the ESCC cases, the positive rate of Bmi-1 and aberrant rate of β-catenin were corelated with depth of invasion, degree of differentiation and lymph node metastasis of ESCC (P<0.05), and positive rate of SALL4 was correlated with the clinical staging (P<0.05) and lymph node metastasis of ESCC (P<0.01). The expression of SALL4, Bmi-1 and β-catenin in the 123 cases of ESCC were positively correlated with each other (SALL4 and Bmi-1: r=0.373,P<0.01; SALL4 and β-catenin: r=0.214, P<0.05; Bmi-1 and β-catenin: r=0.204, P<0.05). Conclusion SALL4, Bmi-1 and β-catenin might be involved in the development, progression, invasion and metastasis of ESCC; and the three of them might interact through corresponding signal pathways. |
| Key words: esophageal neoplasms squamous cell carcinoma SALL4 Bmi-1 β-catenin |
