| 摘要: |
| 脂质具有重要的生物功能, 其代谢与多种疾病的发生、发展密切相关。脂质分析对疾病的发生机制、生物标志物的发现、诊断治疗以及新药研究都有非常重要的意义。脂质组学就是对生物样品中的脂质及其相互作用的分子进行系统的分析。本文就脂质的生物功能以及脂质组学在微生物领域中的分析方法及研究现状作简要评述, 并展望了脂质组学在该领域的应用前景。 |
| 关键词: 脂质组学 质谱分析法 微生物学 生物学标记 |
| DOI：10.3724/SP.J.1008.2014.01368 |
| 投稿时间：2013-08-30修订日期：2014-11-02 |
| 基金项目: |
|
| Lipidomics in microbiology: research progress |
| YANG Yu1,CAO Ying-ying2,ZHU Zhen-yu1* |
(1. Department of Drug Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;
2. New Drug R&D Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Lipids play important biological roles and their metabolism is closely related to the development and progression of a variety of diseases. Lipid analysis is of great importance for research on disease mechanisms, biomarker discovery, diagnosis and treatment, and drug research. Lipidomics systematically analyze the lipids and molecules that interact with lipids in biological samples. This review introduces the biological roles of lipids and the analytical methods regarding lipidomics in microbiology, and offers a future view of lipidomics in microbiology. |
| Key words: lipidomics mass spectrometry microbiology biological markers |
