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| 过氧化物酶6肺部抗氧化应激研究进展 |
| 梁豪君1,原铭贞1,王司仪1,刘笑玎1,高歌1,刘相良1,李波1*,董春玲2* |
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(1. 吉林大学基础医学院人体解剖学系, 长春 130021;
2. 吉林大学第二医院呼吸内科, 长春 130041
*通信作者) |
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| 摘要: |
| 氧化应激诱导的肺泡上皮细胞凋亡和损伤在肺部疾病中的作用受到广泛的关注和重视。过氧化物酶6(peroxiredoxin 6, Prdx6)兼有谷胱甘肽(glutathione, GSH)过氧化物酶和磷脂酶A2(phospholipase A2, PLA2)活性,能有效对抗氧化应激,减轻氧化应激诱导的肺部损伤,在肺部疾病中扮演重要角色。本文通过对Prdx6的结构、功能、分布、表达调控等方面进行回顾,并进一步结合相关实验研究,对Prdx6在肺部抗氧化过程中发挥的作用和调控机制等作一综述。 |
| 关键词: 硫氧还蛋白过氧化物酶Ⅵ 氧化性应激 细胞凋亡 肺疾病 |
| DOI：10.3724/SP.J.1008.2014.01121 |
| 投稿时间：2014-02-14修订日期：2014-05-25 |
| 基金项目:国家自然科学基金(81100030)，吉林省科技发展计划项目(20130522022JH)，吉林省中医药管理局项目(2012-135)，吉林大学科学前沿与交叉学科创新项目(450060491515)，吉林大学创新训练项目(2012A71198，2012C71312). |
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| Antioxidant defense of peroxiredoxin 6 in lung: recent progress |
| LIANG Hao-jun1,YUAN Ming-zhen1,WANG Si-yi1,LIU Xiao-ding1,GAO Ge1,LIU Xiang-liang1,LI Bo1*,DONG Chun-ling2* |
(1. Department of Human Anatomy, College of Basic Medical Sciences, Jilin University, Changchun 130021, Jilin, China;
2. Department of Respiratory Medicine, Second Hospital, Jilin University, Changchun 130041, Jilin, China
*Corresponding authors) |
| Abstract: |
| Alveolar epithelial apoptosis and injury induced by oxidative stress in pulmonary diseases have drawn great attention from researchers. Peroxiredoxin 6 (Prdx6), endowed with the activities of both glutathione (GSH) peroxidase and phospholipase A2 (PLA2), can effectively fight against oxidative stress and alleviate oxidative stress-induced lung injury, and therefore plays an important role in pulmonary diseases. This review focuses on the structure, function, distribution and expression regulation of Prdx6, and summarizes the role of Prdx6 in pulmonary antioxidant defense and its regulatory mechanism based on experimental studies. |
| Key words: peroxiredoxin Ⅵ oxidative stress apoptosis lung diseases |
