| 摘要: |
| 目的 通过病例-对照研究及meta分析探讨ABO血型系统与胃癌发生风险的关系。方法 通过收集长海医院930胃癌患者及8426例非胃癌患者进行病例-对照研究，并检索Pubmed数据库，检索起始时间不限，截止时间为2013年12月31日。将笔者所做病例-对照研究一并纳入分析，由2名研究者独立筛取文献并提取数据，采用NOS量表进行文献质量评价，采用Meta-Analyst 3.13软件进行Meta分析。结果 病例-对照研究提示：血型A是胃癌发生的可能危险因子（OR=1.58；95%CI：1.37~1.81）；Meta分析结果显示：血型A较非A血型增加胃癌发生风险（OR=1.28；95%CI：1.01~1.62），血型O发生胃癌风险低于非O血型（OR=0.84；95%CI：0.73~0.96），但亚组分析发现结果在国内外人群中存在差异。结论 ABO血型系统与胃癌发生风险存在关联，血型A是胃癌发生的危险因子之一，且结果存在国内外差异。 |
| 关键词: 胃癌 ABO血型 Meta分析 NOS量表 危险因子 |
| DOI：10.3724/SP.J.1008.2014.00560 |
| 投稿时间：2013-09-28修订日期：2014-03-18 |
| 基金项目: |
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| ABO blood group and the risk of gastric cancer: a case-control study and meta-analysis |
| 王在标,yinmanman,caihui,libo,zhaoxin,maliye |
| (Department of General Surgery, Changhai Hospital, Second Military Medical University) |
| Abstract: |
| Objective To evaluate the relationship between ABO blood group system and the risk of gastric cancer by performing a case-control study and meta-analysis. Methods In our case-control study, 930 cases of gastric cancer and 8426 cases with other diseases were enrolled as control, Which were collected from changhai hospital. And the Pubmed were searched, the initial time is unlimited, the deadline is December 31, 2013. Two reviewers evaluated the quality of the included case-control studies by NOS scale and extracted the data independently. The meta-analysis was performed by Meta-Analyst 3.13 software. Results The case-control study showed that blood type A might be a risk factor of gastric cancer（OR=1.58；95%CI：1.37~1.81）. The results of meta-analysis showed that the risk of gastric cancer in blood group A was significantly higher than that in non-A groups (OR=1.28；95%CI：1.01~1.62) and individuals with blood group O demonstrated a low risk of gastric cancer(OR=0.84；95%CI：0.73~0.96), But subgroup analysis found that there were differences at home and abroad. Conclusion ABO blood group system is associated with the risk of gastric cancer; Type A is one of the risk factors of gastric cancer, and there are differences at home and abroad. |
| Key words: gastric cancer ABO blood group meta-analysis NOS scale risk factor |
