| 摘要: |
| 长链非编码RNA(long noncoding RNA,lncRNA)是一类长度超过200个核苷酸的非编码RNA分子,其数量众多,但缺少蛋白质编码功能。研究发现,lncRNA能在表观遗传学、转录及转录后等多种水平调控基因的表达,在各类生物过程中起着重要的调节作用,并与多种疾病相关,已经成为现代遗传学的研究热点。近期研究证据显示,肺癌中有多种lncRNA的表达水平发生了变化,并在肺癌的发生、发展及预后中起着重要的调控作用。本文就lncRNA的定义、功能机制及与肺癌的相关性研究作一综述。 |
| 关键词: 长链非编码RNA 肺肿瘤 基因表达调控 |
| DOI：10.3724/SP.J.1008.2014.01115 |
| 投稿时间：2014-02-13修订日期：2014-05-15 |
| 基金项目:国家自然科学基金(81000006)，第二军医大学创新基金重点项目(ZD2013011)，上海市浦江人才计划(14PJ1411000). |
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| Long noncoding RNAs and lung cancer |
| CHEN Jie△,ZHU Cheng-jie△,SHANG Yan*,BAI Chong,LI Qiang |
(Department of Respiratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
△Co-first authors.
*Corresponding authors) |
| Abstract: |
| Long noncoding RNAs (lncRNAs),contraining more than 200 nucleotides,are RNA transcripts without protein-coding capacity.It has been reported that lncRNAs regulate gene expression at the epigenetic,transcriptional and post-transcriptional levels,and are deeply involved in various biological processes.Many diseases are found related to lncRNAs and they have become a focus of studies.According to recent evidences,a number of lncRNAs are changed in lung cancer,and they play a significant part in the development,progression and prognosis of lung cancer.This review focuses on the definition and functional mechanism of lncRNAs and their relation with lung cancer. |
| Key words: long noncoding RNAs lung neoplasms gene expression regulation |
