| 摘要: |
| 目的 观察利舒卡气雾剂对双腔支气管导管插管反应和术后咽痛、声嘶的影响。 方法 择期行肺叶切除术患者60例，ASAI-II级，随机分为利舒卡组（A组）20例、对照组1组(B组）20例和对照2组（C组）20例。常规麻 醉诱导后，A组患者在插管前对准咽喉和声门处喷利舒卡气雾剂3揿，B组和C组喷生理盐水，C组喉镜暴露声门前静脉追加异丙酚0.5mg/kg，芬太尼1μg /kg。分别记录麻醉诱导前（T0）、插管即刻（T1）、插管后1min（T2）、3min（T3）、5min（T4）、10min（T5）时患者的收缩压（SBP）、心率（HR）和心肌氧耗（HR*SBP）以及术后1h、6h、24h咽痛、声嘶的例数。结果 全麻诱导后三组患者T1时HR、SBP、RPP均明显低于T0时（P<0.05）；T2、T3时B组和C组患者在时HR、SBP、RPP均明显高于A组（P<0.05）； T4、T5时C组患者SBP明显低于A组（P<0.05）。A组患者术后1h、6h、24h咽痛和声嘶的发生率显著低于B、C组（P<0.05）。结论 利舒卡气雾剂能有效抑制双腔支气管插管所致的心血管反应，减少麻醉诱导药物用量，降低患者术后咽痛、声嘶的发生率。 |
| 关键词: 利舒卡气雾剂 双腔支气管 心血管反应 声嘶 咽痛 |
| DOI：10.3724/SP.J.1008.2014.01284 |
| 投稿时间：2014-02-09修订日期：2014-04-21 |
| 基金项目: |
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| Effect of lidocaine aerosol on cardiovascular response and postoperative sore throat, hoarseness in patients receiving double lumen tube intubation |
| ZENG Lin1△,LI Yong-hua2△,YI Ming-bo1,LI Wei1* |
(1. Department of Anesthesiology, Second People's Hospital of Pingxiang, Pingxiang 337000, Jiangxi, China;
2. Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
△Co-first authors.
*Corresponding authors) |
| Abstract: |
| Objective To observe the effect of lidocaine aerosol on preventing cardiovascular response and sore throat, hoarseness in the patients with double lumen tube to orotracheal intubation. Methods 60 selective patients (ASAⅠ-Ⅱ) scheduled for lung lobectomy were randomly divided into 3 groups, with 20 cases in each group. Lidocaine aerosol (group A) and Saline as a control (group B and group C) were given to spray. After routine induction, the glottis was exposed and 3 press lidocaine aerosol were given in group A, while group B and C were given saline. Patients in group C were received additional 0.5mg/kg of propofol and 1μg /kg of fentanyl intravenously before the exposure of glottis. HR, SBP, DBP, HR*SBP were monitored and recorded at the time points of pre-induction (T0), immediately pre-intubation (T1), 1 min (T2), 3 min (T3), 5min (T4) , 10min(T5) after intubation. Cases of sore throat and hoarseness were also recorded at the point of 1h, 6h, 24h postoperation. Results Compared with T0, values of HR, SBP and RPP at T1 were significantly decreased after induction（P<0.05）. Values of HR, SBP ,RPP in group B and C were higher than that in group A at T2 and T3（P<0.05）. SBP was significantly decreased at T4 and T5 in group C（P<0.05）.Cases of postoperative sore throat and hoarseness in group A were significantly lower than that in group B and C（P<0.05）. Conclusion Lidocaine aerosol can effectively suppress cardiovascular responses caused by double lumen tube intubation, decrease the dose of induction drugs, reduce the incidence of postoperative sore throat and hoarseness. |
| Key words: lidocaine aerosol double lumen tube cardiovascular responses sore throat hoarseness |
