| 摘要: |
| 帕金森病是以中脑黑质多巴胺能神经元病变和胞内路易小体形成为特征的疾病。氧化应激导致的α-synuclein蛋白硝基化修饰很可能与帕金森病发生、发展相关。本文简述了α-synuclein和硝基化α-synuclein的理化性质、结构特征,综述了近年来关于其在生理和病理条件下的作用和效应方面的研究进展,并进一步探讨了导致帕金森病发生、发展的可能机制,为防治帕金森病提供新的线索。 |
| 关键词: 帕金森病 α突触核蛋白 硝基化 |
| DOI：10.3724/SP.J.1008.2015.00423 |
| 投稿时间：2014-09-28修订日期：2014-12-06 |
| 基金项目:国家自然科学基金面上项目(81273474,81271798),国家自然科学基金青年项目(31100765). |
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| Nitration of α-synuclein in Parkinson disease: recent progress |
| WANG Yan1,YU Zhong-wang2,ZHU Zhen-yu1* |
(1. Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;
2. Department of Neurobiology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Parkinson disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantial nigra and the formation of intracellular Lewy body. Protein nitration due to oxidative and nitrative stress has been linked to the pathogenesis of PD. Here we described the biophysical and biochemical properties of α-synuclein and nitrated α-synuclein protein and reviewed their biological consequences; finally we discussed their roles in the mechanism and prevention/treatment of PD. |
| Key words: Parkinson disease α-synuclein nitration |
