| 摘要: |
| 目的 观察Roux-en-Y胃旁路术（Roux-en-Y gastric bypass，RYGB）及迷走神经肝支对2型糖尿病大鼠降糖效果及空腹血清胰高血糖素样肽-1（GLP-1）的影响及交互作用。方法 将45只2型糖尿病建模成功大鼠分成假手术组（S组，n=10）、假手术+迷走神经肝支切断组（SV组，n=11）、RYGB组（n=12）、RYGB 迷走神经肝支切断组（RYGBV组，n=12）。检测术前及术后各组大鼠体质量、空腹血糖、空腹血浆胰岛素、空腹血清GLP-1，分析RYGB和迷走神经肝支对空腹血清GLP-1的影响。结果 与S组、RYGBV组比较，RYGB 组的2型糖尿病大鼠体质量下降（P<0.05），空腹血清GLP-1和胰岛素水平提高（P<0.05）；RYGB组大鼠空腹血糖水平较S组降低（P<0.05），与RYGBV组比较差异无统计学意义。RYGB对空腹血清GLP-1影响的主效应大于迷走神经肝支，两者存在交互作用（P<0.05）。结论 RYGB对2型糖尿病具有较好的治疗效果，RYGB术中应当注意保护迷走神经肝支。 |
| 关键词: 迷走神经肝支 胃旁路术 2型糖尿病 胰高血糖素样肽-1 |
| DOI：10.3724/SP.J.1008.2014.00938 |
| 投稿时间：2014-03-04修订日期：2014-07-19 |
| 基金项目: |
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| Impact of gastric bypass treatment and hepatic branch of the vagus on hypoglycemic outcome in rats with type 2 diabetes |
| ZHANG Qin,LI Xiao-ke,QIU Nian-cun,SONG Xin,QIU Ming,SHAN Cheng-xiang* |
(Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
* Corresponding author.) |
| Abstract: |
| Objective To observe the effect of Roux-en-Y gastric bypass (RYGB) treatment and hepatic branch of the vagus on hypoglycemic outcome and glucagon-like peptide-1(GLP-1) in rats with type 2 diabetes, and the interaction of between the two. Methods Totally 45 type 2 diabetic rats were divided into four groups: sham operation (S group, n=10), sham operation with hepatic branch of the vagus resected (SV group, n=11), RYGB group (n=12), and RYGB with hepatic branch of the vagus resected (RYGBV group, n=12). The body mass, fasting blood-glucose (FBG), fasting serum insulin (FINS) and concentrations of fasting serum GLP-1 were examined before and after surgery. Effects of RYGB and the hepatic branch of the vagus on GLP-1 levels were analyzed. Results Compared with S group and RYGBV group, RYGB group had significantly decreased body mass(P<0.05) and significantly improved levels of serum GLP-1 and insulin (P<0.05); FBG level in RYGB group was significantly lower than that in S group (P<0.05) and similar to that in RYGBV group. The effect of RYGB on fasting serum GLP-1 was stronger than that of liver branch of the vagus nerve, and there was interaction between the two (P<0.05). Conclusion RYGB treatment has satisfactory treatment effect for type 2 diabetes, and care should be taken during RYGB surgery to preserve the hepatic branch of the vagus. |
| Key words: hepatic branch of the vagus gastric bypass type 2 diabetes glucagon-like peptide-1 |
