| 摘要: |
| 目的 对中国南海棘体海绵Acanthella cavernosa的次生代谢产物进行分离鉴定.方法 运用硅胶柱色谱、凝胶柱色谱、高效液相色谱等分离手段,对棘体海绵Acanthella cavernosa的丙酮提取物进行分离纯化,根据现代波谱技术结合文献报道进行结构鉴定.结果和结论 共分离得到7个化合物,分别鉴定为kalihinene X~Z (1 ~ 3)、(R)-3,5-diethyl-5-[(S,E)-2-ethylhex-3-en-1-yl] furan-2(5H)-one (4)、 methyl(2Z,6R,8S)-4,6-diethyl-3,6-epoxy-8-methyldodeca-2,4-dienoate (5)、 methyl(2Z,6R,8R,9E)-3,6-epoxy-4,6,8-triethyl-2,4,9-dodecatrienoate (6)、methyl(2Z,6R,8S)-3,6-epoxy-4,6,8-triethyldodeca-2,4-dienoate (7).化合物4 ~ 7为首次从Acanthella属中分离得到的聚酮类化合物. |
| 关键词: 海绵 次生代谢产物 结构鉴定 |
| DOI：10.3724/SP.J.1008.2015.00103 |
| 投稿时间：2014-04-02修订日期：2014-11-02 |
| 基金项目:海南省重点科技计划项目(ZDXM20110036), 海南省自然科学基金(811223), 海南省社会发展科技专项资金项目(SF201342), 海南省卫生厅科学研究课题(琼卫-99-23), 国家(省)重点科技项目三亚市配套资金(2012PT17). |
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| Secondary metabolites of South China Sea sponge Acanthella cavernosa: isolation and identification |
| FAN Wei,CAI Hai-min,SUN Li-guang,WANG Xu-dong*,NIE Sui-feng* |
(Department of Pharmaceutics, No. 425 Hospital of PLA, Sanya 572000, Hainan, China
*Corresponding authors) |
| Abstract: |
| Objective To investigate the secondary metabolites of the South China Sea sponge Acanthella cavernosa. Methods The acetone extract of A. cavernosa was purified by repeated column chromatography on silica gel, sephadex LH-20, and high-performance liquid chromatography (HPLC). Structures of the extract were determined by spectroscopic analysis and comparison with previously reported data. Results and Conclusion A total of 7 compounds were isolated and their structures were identified as kalihinene X-Z (1 - 3), (R)-3,5-diethyl-5-((S,E)-2-ethylhex-3-en-1-yl)furan-2(5H)-one (4), methyl(2Z,6R,8S)-4,6-diethyl-3,6-epoxy-8-methyldodeca-2,4-dienoate (5), methyl(2Z,6R,8R,9E)-3,6-epoxy-4,6,8-triethyl-2,4,9-dodecatrienoate (6), and methyl(2Z,6R,8S)-3,6-epoxy-4,6,8-triethyldodeca-2,4-dienoate (7); and compounds 4 - 7 were identified from the genus Acanthalla for the first time. |
| Key words: sponge secondary metabolites structure identification |
