| 摘要: |
| 目的：通过1:1匹配的病例对照研究探讨研究甲状腺相关眼病与A型性格的关系并分析了甲状腺相关眼病发病的危险因素。方法：选取2013年10月至2014年2月份在上海长征医院眼科门诊以及住院诊断为甲状腺相关眼病的以及年龄为18岁至65岁初发患者和身体健康的就诊者共201名。统一采用《人格心理学》2012年8月第一版第一次印刷的符合我国国情的A型性格测试问卷进行调查，剔除测谎题L分大于等于7分时的问卷81份后，收集甲状腺相关眼病的患者60例，健康对照60例共120例。两组病例按年龄，文化程度（高中以上），婚姻1:1配对设计，入选性别（女性），有甲状腺相关眼病家族史，A型性格类型为危险因素，运用多因素条件Logistic回归分析进行病例对照研究。结果:多因素条件Logistic回归分析结果（表二)显示女性，有Graves病家族史以及A型性格均为甲状腺相关眼病发病的危险因素，其中多因素分析中A型性格的OR值为4.571(90%CI：1.912-10.926)，P值为0.0041，提示A型性格与甲状腺相关眼病之间存在明显的关联关系。结合单因素分析的结果，可知TH(time hurry:时间紧迫型)因素对于甲状腺相关眼病有较为明显的影响，其OR值为1.126(95%CI：1.029-1.233）.结论：A型性格,女性和有甲状腺相关眼病家族史均是甲状腺相关眼病的危险因素，其中A型性格尤其是TH(时间紧迫感)是甲状腺相关眼病发病的重要的危险因素。A型性格的人应该调整过分时间紧迫感，保持良好的情绪有利于甲状腺相关眼病的防治以及康复。 |
| 关键词: 甲状腺相关眼病 A型性格 病例对照研究 logistic模型 危险因素 |
| DOI：10.3724/SP.J.1008.2014.01277 |
| 投稿时间：2014-04-07修订日期：2014-10-30 |
| 基金项目:国家自然科学基金(81371056). |
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| The relationship between type A personality and thyroid-associated ophthalmology |
| HE Jie,WEI Rui-li* |
(Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai 200443, China
*Corresponding authors) |
| Abstract: |
| Objective:Through the 1:1 matched case-control study to investigate the relationship of thyroid-associated ophthalmopathy with type A personality and analyzed the risk factors of thyroid-associated ophthalmopathy.Methods:From 2013 October to 2014 February in Department of ophthalmopathy of Shanghai Changzheng Hospital outpatient and inpatient diagnosis of thyroid-associated ophthalmopathy and the age is 18 years old to 65 years old primary patients and healthy patients, a total of 201.The unity of "Psychology of personality" in 2012 August, the first edition of the first printed in line with China"s national conditions of the Type A Personality Questionnaire survey, Remove the Polygraph questions the L greater than or equal to 7 of the 81 questionnaires, collected 60 cases of thyroid-associated ophthalmopathy patients, and 60 healthy controls were enrolled a total of 120 cases.Two groups of patients by age, culture level (high school and above), the marriage 1:1 paired design, inclusion sex (female), family history of thyroid-associated ophthalmopathy, type A personality types as risk factors, using the mult-factor conditional Logistic regression analysis of case-control study.Result:the results of Multi factor Logistic regression analysis of thyroid associated ophthalmopathy and type A personality of showed that women, family history of Graves disease is a risk factor for thyroid associated ophthalmopathy, according with the literature,multivariate analysis showed that Type A personality OR value was 4.571 (90%CI:1.912-10.926), the P value is 0.0041, suggesting that the existence of the obvious relationship between the type A behaviour personality and thyroid associated ophthalmopathy.Combined with the results of single factor analysis, the TH (time hurry: time is pressing type) factors have obvious influence on thyroid associated ophthalmopathy, the value of OR was 1.126 (95%CI:1.029-1.233).Type A behaviour pattern was shown to be an independent risk factor for the development of TAO.
Conclusion:the type A behaviour personality is conducive to thyroid associated ophthalmology prevention and rehabilitation.A personality, women and family history of thyroid associated ophthalmopathy were risk factors for thyroid associated ophthalmopathy, the type A personality especially TH (time urgency) is an important risk factor in the incidence of thyroid associated ophthalmopathy.People with type A personalities should be adjusted over time urgency, keeping a good mood is conducive to thyroid associated ophthalmology prevention and rehabilitation. |
| Key words: thyroid-associated ophthalmopathy type A personality case-control studies logistic models risk factors |
