| 摘要: |
| 结肠癌干细胞(colon cancer stem cells, CCSCs)在肿瘤发生、增殖、转移以及化学抵抗中发挥重要作用。目前关于CCSCs标记物的研究较多,而对CCSCs增殖、转移、化学抵抗等生物学行为机制的报道较少。本文就近几年CCSCs生物学特性的相关机制研究作一综述,尤其重点阐述microRNAs对CCSCs的调控作用,为临床改善和提高结肠癌的诊断和治疗水平提供参考。 |
| 关键词: 结肠癌 干细胞 细胞增殖 肿瘤转移 肿瘤抗药性 |
| DOI：10.3724/SP.J.1008.2014.01262 |
| 投稿时间：2014-04-11修订日期：2014-10-22 |
| 基金项目:安徽省自然科学研究重点项目(KJ2014A147). |
|
| Biological characteristics of colon cancer stem cells: recent progress |
| CHEN Fang-jun1,2,LIU Yu-lan1*,ZHANG Yu-jun1,SUN Guo-ping3 |
(1. Department of Gastroenterology, Peking University People's Hospital, Beijing 100044, China;
2. Anqing Medical College, Anqing 246052, Anhui, China;
3. Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui, China
*Corresponding authors) |
| Abstract: |
| Colon cancer stem cells(CCSCs)play key roles in tumor initiation, proliferation,metastasis,and chemoresistance. Currently a large number of reports focused on markers of CCSCs, with relative less reporting on CCSCs biological characteristics: proliferation, metastasis, and chemoresistance. This paper reviewed the current research on the biological behavior of CCSCs, with special attention paid on the regulatory effects of microRNAs on CCSCs, hoping to provide reference for improving the diagnosis and treatment of colon cancer. |
| Key words: colonic neoplasms stem cells cell proliferation neoplasm metastasis neoplasm drug resistance |
