| 摘要: |
| 隧道纳米管(tunneling nanotubes,TNT)是近年来发现的新型动物细胞间的连接方式。 其形成伴有重要的生理、病理意义。但TNT的形成条件、促进机制尚不完全清楚。已知细胞状态(炎症条件和应激反应)、分子层面(Fas配体、细胞黏附分子和受-配体交互作用、M-Sec/TNFaip2/B94及脂质分子)、病原微生物感染对其形成有重要促进作用。本文就TNT形成促进机制作一综述。 |
| 关键词: 细胞间接合部 隧道纳米管 细胞学 分子生物学 微生物学 |
| DOI：10.3724/SP.J.1008.2015.1229 |
| 投稿时间：2015-03-28修订日期：2015-08-18 |
| 基金项目:国家自然科学基金(81200924,81230027),上海市自然科学基金(12ZR1427400). |
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| Progress in promoting mechanism of tunneling nanotubes formation |
| WANG Xiao-qing1,YU Xiao-wen2,LIU Ming-yuan1,GUAN Yang-tai1,3* |
(1. Department of Neurology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
2. Department of Geriatrics, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
3. Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
*Corresponding author.) |
| Abstract: |
| Tunneling nanotubes (TNT) is a newly discovered connection mode between animal cells, and its formation is of great importance in physiological and pathological processes of animals and humans. The forming conditions and the promoting mechanism of TNT are not fully understood yet. It has been known that the state of cells (such as inflammatory conditions and stress reaction), molecular level (Fas ligand, cell adhesion molecules and the ligand interactions, M-Sec/TNFaip2/B94 and lipid molecules), and pathogenic infection are important for the formation of TNT. In this paper we reviewed the promoting mechanisms for TNT formation. |
| Key words: intercellular junctions tunneling nanotubes cytology molecular biology microbiology |
