| 摘要: |
| 硫化氢(H2S)是继一氧化氮(NO)和一氧化碳(CO)之后的第3种内源性气体信号分子。研究显示H2S对神经系统、呼吸系统、消化系统和心血管系统具有调节效应,在正常生理功能和病理生理过程的调控中发挥重要生物学作用。近年来,H2S的中枢心血管调节作用逐渐引起重视,并表现出复杂的调节效果。本文主要介绍H2S对血压调节中枢相关核团的作用特点,并分析H2S在中枢心血管功能调控中的意义及其进展。 |
| 关键词: 硫化氢 心血管系统 孤束核 延髓头端腹外侧区 室旁核 |
| DOI：10.3724/SP.J.1008.2015.00193 |
| 投稿时间：2014-06-17修订日期：2014-08-08 |
| 基金项目:国家自然科学基金(81070214,81170240,31100831),第二军医大学大学生创新能力培养基金(ZD2013019). |
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| Role of hydrogen sulfide in central cardiovascular regulation |
| ZHAO Sheng-bing,TAN Xing,WANG Wei-zhong* |
(Department of Physiology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Hydrogen sulfide (H2S) is the third endogenous gaseous mediator following nitric oxide and carbon monoxide. It has been demonstrated that H2S plays important regulatory roles in modulating the physiological and pathophysiological processes of the nervous system, respiratory system, digestive system, and cardiovascular system. Recently, regulatory roles of H2S in cardiovascular system are widely focused and seem to be complex. Here we sum up the roles of H2S in mediating the cardiovascular regulation and illustrate its underlying mechanisms and perspectives. |
| Key words: hydrogen sulfide cardiovascular system nucleus of solitary tract rostral ventrolateral medulla paraventricular nucleus |
