| 摘要: |
| P2X7受体是ATP-门控的阳离子通道,具有广泛的生物学效应,在多种组织细胞中均有表达,包括成骨细胞和破骨细胞,参与骨代谢,在骨形成和骨吸收过程中发挥重要作用.本文着重对P2X7受体及其相关信号通路对骨代谢影响的相关研究进展作一综述. |
| 关键词: P2X7受体 骨代谢 成骨细胞 破骨细胞 |
| DOI：10.3724/SP.J.1008.2015.00767 |
| 投稿时间：2014-08-24修订日期：2015-03-10 |
| 基金项目: |
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| Relationship between P2X7 receptor and bone metabolism: recent progress |
| LI Zhe1,2,MA Bei3*,CHEN Ai-ming2* |
(1. Medical Team, No. 73018 Troop of PLA, Zhenjiang 212416, Jiangsu, China;
2. Department of Orthopaedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;
3. Experimental Training Center for Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China
*Corresponding authors) |
| Abstract: |
| P2X7 receptor, an ATP-gated ion channel, is widely found in various tissues and possesses multiple physiological functions. Recent reports have implicated expression of P2X7 receptor in both osteoblasts and osteoclasts, participating in both bone formation and resorption. This paper reviews the recent progresses on the influence of P2X7 receptor and its related pathways on bone metabolism. |
| Key words: P2X7 receptor bone metabolism osteoblasts osteoclasts |
