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| 经皮急性主动脉瓣关闭不全犬模型的建立 |
| 黄松群1Δ,谭洪文2Δ,陈翔3,朱玉峰1,秦永文1,赵仙先1* |
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(1. 第二军医大学长海医院心血管内科, 上海 200433;
2. 贵州省人民医院心血管内科, 贵阳 550002;
3. 复旦大学附属中山医院心血管内科, 上海 200023
△共同第一作者
*通信作者) |
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| 摘要: |
| 目的 探讨通过经外周血管经导管微创的方法建立主动脉瓣关闭不全犬模型的可行性和有效性。 目的 选择健康犬10只,经皮经股动脉途径穿刺及扩张主动脉瓣,建立主动脉瓣关闭不全模型。手术后即刻通过主动脉瓣上造影及经胸超声确定主动脉瓣反流程度。 结果 10只实验犬即时主动脉瓣关闭不全模型均成功建立。其中2只因主动脉瓣反流量过大致急性左心衰当场死亡。存活犬中6只为主动脉瓣中量反流,2只为少量反流。术后动物存活时间超过1个月。 结论 经外周血管经导管微创的方法建立主动脉瓣关闭不全犬模型可行。 |
| 关键词: 经导管 主动脉瓣关闭不全 动物模型 犬科 |
| DOI：10.3724/SP.J.1008.2015.01123 |
| 投稿时间：2015-04-12修订日期：2015-07-23 |
| 基金项目:中国博士后科学基金 (2014M551330). |
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| Establishment of a canine model of a percutaneous acute aortic valve regurgitation |
| HUANG Song-qun1Δ,TAN Hong-wen2Δ,CHEN Xiang3,ZHU Yu-feng1,QIN Yong-wen1,ZHAO Xian-xian1* |
(1. Department of Cardiovasology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
2. Department of Cardiovasology, Guizhou Provincial People's Hospital, Guiyang 550002, Guizhou, China;
3. Department of Cardiovasology, Zhongshan Hospital, Fudan University, Shanghai 200023, China
△Co-first authors.
*Corresponding author.) |
| Abstract: |
| Objective To explore the feasibility and effectiveness of establishing an aortic valve regurgitation canine model by minimally invasive peripheral vascular catheter method. Methods A total of 10 healthy canines were selected in this study. An aortic insufficiency animal model was established by percutaneous femoral artery puncture and aortic dilatation. Aortic angiography and transthoracic echocardiography were used to evaluate aortic valve regurgitation immediately after operation. Results Aortic valve regurgitation animal models were successfully established in all the 10 canines. Two canines died of acute left ventricular failure due to the large aortic regurgitation after the operation. Six surviving canines had moderate aortic regurgitation and two had slight aortic regurgitation; they survived for more than 1 month. Conclusion It is feasible to establish an aortic regurgitation canine model by minimally invasive peripheral vascular catheter method. |
| Key words: thanscatheter aortic value insufficiency animal models canidae |
