| 摘要: |
| 目的 探讨肺炎支原体感染与过敏反应的关系并阐明其中的机制。方法 以败血症患儿及健康儿童为对照,检测2012年1月至2013年12月期间在我院呼吸科住院的肺炎支原体感染患儿血清中细胞因子谱的变化及IgE水平。结果 肺炎支原体感染的患儿与健康儿童相比IL-4, IL-6和IL-10这些Th2类细胞因子水平显著升高。败血症患儿与健康儿童相比虽然IL-6和IL-10升高更显著,但是IL-4水平却无显著变化,另外肺炎支原体感染的患儿和败血症患儿与健康儿童相比,又只有肺炎支原体感染患儿的血清IgE水平发生了显著的升高。结论 由此可见肺炎支原体感染患儿IL-4水平上调是其血清IgE水平升高的决定因素。同时也表明肺炎支原体感染的过程中发生了Th1/Th2失衡。 |
| 关键词: 肺炎支原体 过敏 免疫调节 免疫球蛋白E |
| DOI：10.16781/j.0258-879x.2016.04.0521 |
| 投稿时间：2015-10-07修订日期：2015-12-22 |
| 基金项目:国家自然科学基金青年项目(81501760);浙江省自然科学基金青年项目(LQ16H050002);浙江省卫生计生委科技计划项目(2015KYB191). |
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| Relationship between Mycoplasma pneumoniae infection and secondary allergic diseases in children |
| SHAO Wen-xia1,2,YE Qing3,WANG Qing-qing1*,WANG Xian-jun2 |
(1. Department of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China;
2. Clinical Laboratory, First People's Hospital of Hangzhou, Hangzhou 310006, Zhejiang, China;
3. Clinical Laboratory, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310005, Zhejiang, China
*Corresponding author) |
| Abstract: |
| Objective We sought to determine the relationship between MP infection and secondary allergic disease and to clarify the associated mechanisms. Methods A prospective study was performed to investigate the patient’ immune status by determining serum cytokines spectrum and immunoglobulin E (IgE) levels, and to compare these indicators with sepsis patients and healthy children. Results Comparing with healthy children, children with mycoplasma pneumoniae infection Th2 cytokines, such as, IL - 4, IL - 6 and IL - 10 increased significantly. Comparing with healthy children, sepsis patients’ IL - 6 and IL - 10 levels raised significantly, but there was no significant change on IL - 4 level. Only when children infected with mycoplasma pneumoniae, the serum IgE level significantly increased. Conclusion When children with mycoplasma pneumoniae infection, the serum IgE level significantly increased, IL-4 level is the key factor for determining serum IgE levels. ThisSstudySalso shows that Th1/Th2 imbalance happened in the process of mycoplasma pneumoniae infection. |
| Key words: Mycoplasma pneumoniae allergy immune regulation immunoglobulin E |
