| 摘要: |
| 胆碱激酶α隶属于胆碱激酶蛋白家族,是CDP-胆碱通路的关键酶。在多种人类肿瘤组织中均发现有胆碱激酶α表达升高,如乳腺癌、结直肠癌、前列腺癌、肺癌等。研究已证实胆碱激酶α与多种肿瘤相关通路存在交互作用。由于其在肿瘤组织中的高表达和异常激活,胆碱激酶α可能是有助于肿瘤诊断的生物标记物,并有望成为肿瘤治疗的新靶点。本文从胆碱激酶α在肿瘤中的生物功能及其在肿瘤诊断及预后评估、肿瘤靶向治疗中的作用等方面综述了胆碱激酶α在肿瘤中的作用。 |
| 关键词: 胆碱激酶α 肿瘤 生物功能 诊断 预后 治疗 |
| DOI：10.16781/j.0258-879x.2016.06.0738 |
| 投稿时间：2015-08-16修订日期：2015-10-11 |
| 基金项目:上海市科委基础研究重点项目(12JC1410900). |
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| The role of choline kinase α in tumorigenesis |
| QI Chen,XU Zhi-fei |
(Department of Thoracic and Cardiovascular Surgery,Second Military Medical University, Changzheng Hospital,Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Choline kinase α (CHOKα), a member of the choline kinase family, is a key enzyme in the CDP-pathway. CHOKα has been reported overexpressed in a wide variety of human tumors including breast cancer, colorectal cancer, prostate cancer, and lung cancer. The interaction between CHOKα and cancer related pathways has been revealed. Due to its overexpression and aberrant activation in cancers, CHOKα is expected to be a potential biomarker and has been demonstrated to be a promising cancer therapeutic target. In this paper we reviewed the role of CHOKα in the tumorigenesis process, biological function, diagnosis and prognosis evaluation and tumor targeting therapy. |
| Key words: choline kinase α neoplasms biological function diagnosis prognosis therapy |
