| 摘要: |
| 黑素瘤是由表皮黑素细胞转化而来的恶性皮肤肿瘤,极易发生转移,具有高度的致死性。黑素瘤表观遗传学研究是目前发展较为迅速的领域,近年来在基因启动子区甲基化、组蛋白修饰、miRNA对靶基因的抑制作用以及lncRNA对染色质结构调节等方面取得了许多新的研究成果,同时,由于表观遗传学改变先于临床诊断和可药物逆转的特性,为人类最终攻克黑素瘤提供了新的思路。本文综述了近年来在黑素瘤表观遗传学研究方面的进展,以细胞周期、细胞凋亡、侵袭迁移、克隆形成、信号通路等细胞功能分析为重点,阐述黑素瘤表观遗传学改变对肿瘤发生、发展以及转移的影响,并展望了表观遗传学方法在黑素瘤预防、诊断、治疗、进展以及预后监测等方面的应用。 |
| 关键词: 黑素瘤 表观遗传学 DNA甲基化 微RNAs 组蛋白修饰 |
| DOI：10.3724/SP.J.1008.2015.00988 |
| 投稿时间：2015-03-21修订日期：2015-05-20 |
| 基金项目:国家自然科学基金(31471236). |
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| Research progress in melanoma epigenetics |
| WANG Dong1,2,ZHAO Hua1,DONG Mei2*,LI Heng-jin1* |
(1. Department of Dermatology, General Hospital of PLA, Beijing 100853, China;
2. Department of Clinical Laboratory, No. 309 Hospital of PLA, Beijing 100091, China
*Corresponding author) |
| Abstract: |
| Melanoma is a malignant cutaneous cancer derived from the epidermal melanocytes, with high potency of metastasis and high lethal rate. Melanoma epigenetics research is gaining fast progress and many new achievements have been made in areas such as gene promoter methylation, histone modification, miRNA inhibiting target gene and lncRNA regulating the structure of chromatin. As the alteration of epigenetics may cast new light on cure of melanoma since it can contribute to clinic diagnosis and drug development. This paper reviewed the progression in melanoma epigenetics, with special attention on cell function analysis such as cell cycle, cell apoptosis, invasion and migration, clone formation, signal pathway, and elaborated how the change of melanoma epigenetics influences tumor cell genesis, progression and metastasis. We also discussed the prospect of epigenetics research in melanoma precaution, diagnosis, therapy, progression and the prognosis monitoring. |
| Key words: melanomas epigenetics DNA methylation microRNAs histone modification |
