| 摘要: |
| 埃博拉病毒(Ebola virus,EBOV)引起的埃博拉病毒病(Ebola virus disease, EVD)是迄今发现的最凶猛的烈性传染病之一。EVD传染性强、死亡率高,目前尚无特效治疗方法。EBOV感染后能够引起机体出现一系列免疫反应,宿主出现特异性及非特异性抗病毒免疫缺陷是EVD 致死的重要原因。本文就EBOV对人体天然免疫功能的影响及其相应对策的研究进展作一综述。 |
| 关键词: 埃博拉病毒 天然免疫 干扰素类 紧密连接部 树突细胞 细胞因子风暴 |
| DOI：10.3724/SP.J.1008.2015.00607 |
| 投稿时间：2015-03-22修订日期：2015-04-04 |
| 基金项目: |
|
| Ebola virus and innate immunity |
| ZHANG Jing-xi1,2*,LI Cheng-zhong1,3,BAI Chong2 |
(1. The Second Medical Team of the Chinese People's Liberation Army to Liberia;
2. Department of Respiratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
3. Department of Infectious Diseases, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding authors) |
| Abstract: |
| Ebola virus disease (EVD) caused by Ebora virus (EBOV) is one of the most violent infectious disease so far. It is so highly infective and fatal that there has been no effective treatment until now. Ebola viral infection can cause a series of immune responses. Specific and nonspecific antiviral innate immune deficiency in the hosts is a recognized important reason for EVD associated death. This paper reviews the influence of EBOV on innate immune reaction of humans and the corresponding countermeasures. |
| Key words: Ebola virus natural immunity interferons tight junctions dendritic cells cytokine storm |
