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| 细胞自噬作用在阿尔茨海默病治疗过程中的作用 |
| 朱朋胤1,姜忠伟2,车皓月3,潘勇华1,高申1,王忠壮1,傅芃1* |
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(1. 第二军医大学长海医院药学部, 上海 200433;
2. 甘肃省军区门诊部, 兰州 730000;
3. 第二军医大学药学院2011级, 上海 200433
*通信作者) |
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| 摘要: |
| 阿尔茨海默病(Alzheimer's disease,AD)是一种以进行性认知障碍和记忆力损害为主的脑部神经退行性疾病,其发病机制尚未明确,目前仍无有效的治疗方法。自噬在清除异常积聚的蛋白以及受损细胞器、维持细胞内稳态和细胞代谢中扮演重要角色。本文对细胞自噬作用在AD治疗过程中的作用进行了综述,以期为发现AD的新的治疗靶点提供参考。 |
| 关键词: 阿尔茨海默病 自噬 淀粉样β蛋白 |
| DOI：10.16781/j.0258-879x.2016.01.0077 |
| 投稿时间：2015-04-10修订日期：2015-05-31 |
| 基金项目:国家自然科学基金(81402819,81373327),上海市自然科学基金(13ZR1408500),总后勤部卫生部基金面上项目(14ZJ202-3). |
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| Role of cell autophagy in treatment of Alzheimer's disease |
| ZHU Peng-yin1,JIANG Zhong-wei2,CHE Hao-yue3,PAN Yong-hua1,GAO Shen1,WANG Zhong-zhuang1,FU Peng1* |
(1. Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;
2. Department of Outpatient, Gansu Provincial Military Area Command of PLA, Lanzhou 730000, Gansu, China;
3. Student of Grade 2011, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| Objective Alzheimer's disease(AD)is a brain neural degenerative disease characterized by progressive cognitive and memory impairment. The pathogenesis of Alzheimer's disease remains unclear and there has been no effective treatment up to now. Autophagy plays an important role in clearing abnormally accumulated proteins and damaged organelles and in maintaining intracellular homeostasis and cell metabolism. This paper reviewed the role of autophagy in treatment of Alzheimer's disease, hoping to provide reference for discovering new treatment target for Alzheimer's disease. |
| Key words: Alzheimer disease autophagy amyloid β-protein |
