| 摘要: |
| 目的 研究纳米银-活性炭纤维敷料对压疮动物模型创面愈合情况的影响。 目的 选择成年SD大鼠,在背部制作压疮, 根据创面覆盖和治疗材料的不同分为5组(n=10),分别为纳米银-活性炭纤维敷料组、纳米银敷料组、活性炭敷料组、洗必泰凡士林敷料组、空白对照组。比较5组大鼠的创面愈合情况、创面组织中血管新生因子和炎性因子的含量。 结果 大鼠的创面愈合时间和愈合率在5组间均有差异,纳米银-活性炭纤维敷料组大鼠的创面愈合时间短于其余4组,差异有统计学意义(P<0.05);压疮后第3、7、14、21 d时,纳米银-活性炭纤维敷料组大鼠的愈合率均高于其余4组,差异均有统计学意义(P<0.05)。大鼠创面组织中的血管新生因子和炎性因子的含量在5组间有差异,纳米银-活性炭纤维敷料组大鼠创面组织中VEGFA、VEGFB、VEGFC的mRNA含量均高于其余4组,TNF-α、IL-2、IL-8的mRNA含量低于其余4组,差异均有统计学意义(P<0.05)。 结论 纳米银-活性炭纤维敷料有助于促进压疮创面愈合、缓解创面炎症反应、促进创面内新生血管形成,是处理压疮创面的理想材料。 |
| 关键词: 压力性溃疡 纳米银 活性炭 血管内皮生长因子类 炎性因子 |
| DOI：10.3724/SP.J.1008.2015.01051 |
| 投稿时间：2015-07-30修订日期：2015-09-30 |
| 基金项目:第二军医大学长海医院"1255"学科建设计划 (CH125550900). |
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| Nano-silver active carbon fiber dressings improving bedsore wound healing in rats |
| WANG Ying1,SONG Jian-xing2*,CHEN Jiang-ping2,LOU Xiao-li2 |
(1. Department of Burns and Plastic Surgery, No. 85 Hospital of PLA, Shanghai 200052, China;
2. Department of Plastic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author.) |
| Abstract: |
| Objective To study the effect of nano-silver active carbon fiber dressings on wound healing in bedsore wound animal models. Methods Adult SD rats were used and bedsore wound models were made on their back; the animals were then randomly divided into 5 groups (n=10) according to different materials of the wound dressing and treatment. Groups were treated with nano-silver active carbon dressings, nano-silver dressings, active carbon dressings, Vaseline chlorhexidine dressings, or blank control. The wound healing situation, contents of angiogenic factors and inflammatory factors in wound tissues were compared among the 5 groups. Results Wound healing time and the healing rates were different among the 5 groups, with the healing time of rats in nano-silver active carbon dressing group being significantly shorter than those in the other 4 groups (P<0.05). On the 3rd, 7th, 14th and 21st days after bedsore wound modeling, the healing rates of nano-silver active carbon dressing group were significantly higher than those of the other 4 groups (P<0.05). The levels of angiogenesis factors and inflammatory factors were different in wound tissues of five groups, with the contents of VEGFA, VEGFB and VEGFC mRNA in nano-silver active carbon dressing group being significantly higher and the contents of TNF-α, IL-2 and IL-8 mRNA being significantly lower than those of the other 4 groups (P<0.05). Conclusion The prepared nano-silver active carbon fiber dressing can help to improve pressure ulcer wound healing, relieve wound inflammation, and promote angiogenesis in the wound; it may serve as an ideal material for treating bedsore wound. |
| Key words: pressure ulcer nano silver activated carbon vascular endothelial growth factors inflammatory factors |
