| 摘要: |
| 目的 通过meta分析探讨ABO血型系统与幽门螺杆菌感染发生的关系。方法 以PubMed、EMBASE、CNKI等作为文献来源数据库，并追溯相关参考文献和引文，进行全面、系统的文献检索。收集ABO血型系统与幽门螺杆菌感染关系的文献研究，根据纳入和排除标准，由2名研究者独立筛选文献、提取数据并进行文献质量评价，采用Review Manager 5.0、Stata 11.0软件进行meta分析、敏感性分析及发表偏倚的评估。以比值比（OR）作为评估ABO血型与幽门螺杆菌感染关系的指标，采用Egger法及漏斗图评价发表偏倚。结果 本研究共纳入文献31篇。敏感性分析的结果显示Lin等的研究明显影响了系统分析的结果，剔除该研究后，重新合并OR值。Meta分析结果表明：ABO血型与幽门螺杆菌感染发生无关（血型A：OR=0.98，95%CI 0.84~1.15，P=0.82；血型B：OR=0.93，95%CI 0.84~1.03，P=0.15；血型O：OR=1.10，95%CI 0.93~1.29，P=0.26；血型AB：OR=0.84，95%CI 0.67~1.06，P=0.14）。Egger法计算结果显示不存在发表偏倚，而漏斗图则显示存在潜在发表偏倚。亚组分析结果也显示ABO血型与幽门螺杆菌感染发生无关。结论 ABO血型与幽门螺杆菌感染的发生无关。 |
| 关键词: ABO血型系统 幽门螺杆菌 感染风险 meta分析 |
| DOI：10.16781/j.0258-879x.2016.11.1378 |
| 投稿时间：2016-03-17修订日期：2016-06-12 |
| 基金项目:国家级大学生创新创业训练计划项目（201510343012），浙江省大学生科技创新活动计划（新苗人才计划）项目（2016R413050）. |
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| ABO blood group and the infection risk of Helicobacter pylori: a meta-analysis |
| ZHU Zhe-hui1△,SONG Yi-zuo1△,CHEN Jin-yong1,XU Hui-ying1,CHEN Bi-cheng1,WU Cun-zao1,YOU He-yi2* |
(1. Laboratory of Surgery Department, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China;
2. Department of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
△Co-first authors.
*Corresponding author) |
| Abstract: |
| Objective To evaluate the relationship between ABO blood group system and the infection risk of Helicobacter pylori (H. pylori) using meta-analysis. Methods A systematic literature review was conducted in databases including PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) to collect case-control studies on ABO blood types and H. pylori infection. According to the established inclusion and exclusion criteria, essential data were extracted from the included studies by two researchers, and Review Manager 5.0 and Stata 11.0 softwares were employed for meta-analysis and sensitivity analysis. Odds ratio (OR) was employed to evaluate the relationship between H. pylori infection and ABO blood group. Assessment of publication bias was evaluated using Egger's test or a funnel plot. Results A total of 31 studies met the inclusion criteria. Sensitivity analyses indicated that Lin et al's study significantly influenced the overall results, and Lin et al's study was screened out and the the pooled OR ratios were calculated again. The result of meta-analysis showed no association between ABO blood group and the infection risk of H. pylori (blood group A:OR=0.98, 95% CI 0.84-1.15, P=0.82; blood group B:OR=0.93, 95%CI 0.84-1.03, P=0.15; blood group O:OR=1.10, 95%CI 0.93-1.29, P=0.26; blood group AB:OR=0.84, 95%CI 0.67-1.06, P=0.14). Egger's test showed that the publication bias exerted little influence on the overall results and funnel plot showed that publication bias existed. Subgroup analysis also found no significant relationship between ABO blood group and H. pylori infection risk either. Conclusion The findings in this analysis indicate that ABO blood groups are not associated with the infection risk of H. pylori. |
| Key words: ABO blood-group system Helicobacter pylori infection risk meta-analysis |
