| 摘要: |
| 炎症小体是机体固有免疫的重要组成部分，目前对NLRP3炎症小体的研究最为热门和透彻。NLRP3炎症小体的活化因素包括病原体及其分泌的毒素、晶体和内源性危险信号等。NLRP3炎症小体的活化需要启动和激活两个步骤，其中启动机制主要针对NLRP3的转录和翻译后修饰水平，激活机制与线粒体、离子流动和溶酶体等相关。本文还综述了NLRP3炎症小体在表达、组装、活化等方面存在的负调控机制。 |
| 关键词: NLRP3炎症小体 活化机制 负调控 固有免疫 炎症性凋亡 |
| DOI：10.16781/j.0258-879x.2016.07.0868 |
| 投稿时间：2015-10-15修订日期：2016-02-26 |
| 基金项目:国家科技重大专项课题（2014ZX09J14106-06C，13CXZ005），国家自然科学基金（81473291，81402651，81402654），上海市自然科学基金（13ZR144940）. |
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| Activation and regulation of NLRP3 inflammasome: research progress |
| LIU Yan-gang,CHEN Yong-chun,ZONG Ying,MA Xiu-juan,CHEN Ji-kuai,YUAN Bo-jun,LU Guo-cai* |
(Department of Health Toxicology, Faculty of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China
* Corresponding author) |
| Abstract: |
| Inflammasome is a vital part of innate immunity, and NLRP3 inflammasome is by far the most thoroughly studied inflammasome complexes that have been described. NLRP3-activating signals include toxins secreted by pathogens, crystalline molecules and endogenous danger signals. Activation of NLRP3 inflammasome needs two steps:priming and activating. The priming step affects NLRP3 at the transcriptional and posttranscriptional modification levels; the activating step is associated with ion flowing, mitochondria and lysosomes. In this paper we also reviewed the negative regulation of NLRP3 inflammasome at the expression, assembly and activation levels. |
| Key words: NLRP3 inflammasome activation mechanism negative regulation innate immunity pyroptosis |
