| 摘要: |
| 外泌体是来源于细胞的膜性囊泡，可以通过运送蛋白质、脂质和核酸到靶细胞而发挥信息和物质传递作用，从而影响靶细胞的生物活性。研究表明，外泌体在阿尔茨海默病、帕金森病、朊病毒病等神经系统疾病的发生过程中具有重要作用，因此外泌体可能在中枢神经系统疾病的治疗方面具有一定的临床应用价值。本文对外泌体的生成及其在中枢神经系统疾病中的研究进展进行了综述。 |
| 关键词: 外泌体 中枢神经系统疾病 阿尔茨海默病 帕金森病 |
| DOI：10.16781/j.0258-879x.2016.12.1524 |
| 投稿时间：2016-05-22修订日期：2016-08-19 |
| 基金项目: |
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| Research progress of exosomes in diseases of the central nervous system |
| ZHANG Ning,ZHANG Rong-jia,SUN Xue-jun* |
(Department of Naval Aeromedicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China
* Corresponding author) |
| Abstract: |
| Exosomes are membrane-derived vesicles of cells, and it can convey information and substances by transporting proteins, lipids and nucleic acids to target cells, thereby affecting the biological activity of target cells. Researches have shown that exosomes play important roles in neurological diseases, such as Alzheimer diseases, Parkinson diseases and prion disease, implying that the study of exosomes may have clinical value for treating central nervous system diseases. In this review, we summarized the generation of exosomes and the recent advances of their roles in neurological disease. |
| Key words: exosomes central nerous system diseases Alzheimer disease Parkinson disease |
