| 摘要: |
| 缺血再灌注损伤(ischemia/reperfusion injury, IRI)是临床上常见的病理生理过程,缺血缺氧是其主要影响因素。低氧诱导因子(hypoxia-inducible factors, HIF)是一组对细胞缺氧反应性和适应性至关重要的转录因子,缺氧环境下会导致HIF激活,从而提高细胞对机体缺氧的耐受能力。HIF在IRI中的作用已成为当今研究热点,阐明其作用机制,不仅有利于减轻IRI,还可以此为基础进一步探讨HIF在其他病理生理过程的作用。本文对HIF的结构、功能及其在IRI中的具体作用及相关机制进行了综述。 |
| 关键词: 低氧诱导因子 再灌注损伤 缺血 缺氧 |
| DOI：10.16781/j.0258-879x.2016.04.0488 |
| 投稿时间：2016-03-11修订日期：2016-04-12 |
| 基金项目:国家自然科学基金(81270830). |
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| Role of hypoxia-inducible factors in ischemia/reperfusion injury: an update |
| TIAN Hong-zhe,ZENG Li* |
(Department of Organ Transplantation, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Ischemia/reperfusion injury (IRI) is a common clinical pathophysiological process characterized by ischemia and hypoxia. Hypoxia-inducible factors (HIFs) are a group of transcription factors vital to cell responding and adapting to hypoxia environment. Hypoxia can activate HIF, thus enhancing the tolerance of cells to hypoxia. The role of HIF in IRI has become a research focus of many scientists. Elucidating the related mechanism can not only help to reduce IRI, but also lay a basis for further studying the role of HIF in other pathophysiological processes. In this paper, we reviewed the structure, function of HIF and the specific role and related mechanisms of HIF in IRI. |
| Key words: hypoxia-inducible factors reperfusion injury ischemia anoxia |
