| 摘要: |
| 目的 观察肥大细胞特异性分泌的类胰蛋白酶在糖尿病性心肌病（DCM）患者中的表达及其与空腹血糖的关系。方法 选取2012年8月至2013年3月在第二军医大学长征医院心内科就诊的DCM患者26例（DCM组）、缺血性心肌病（ICM）患者32例（ICM组）、健康志愿者20例（健康对照组）。收集各组受试者的一般临床资料并检测其空腹血糖等生化指标。采用酶联免疫吸附法检测各组受试者的血浆类胰蛋白酶水平，分析类胰蛋白酶水平与空腹血糖的相关性。结果 3组受试者的一般临床资料和空腹血糖差异均无统计学意义。DCM组和ICM组患者的血浆类胰蛋白酶水平高于对照组[（7.19±0.62）μg/L、（6.81±0.94）μg/L vs（2.37±0.56）μg/L，P<0.01]；DCM组患者的血浆类胰蛋白酶水平高于ICM组，但差异无统计学意义。Pearson相关性分析结果显示，血浆类胰蛋白酶水平与空腹血糖呈正相关（r=0.637，P<0.01）。结论 DCM患者体内的血浆类胰蛋白酶水平升高，且与空腹血糖呈正相关。 |
| 关键词: 糖尿病并发症 心肌病 类胰蛋白酶类 肥大细胞 心脏重构 |
| DOI：10.16781/j.0258-879x.2016.10.1293 |
| 投稿时间：2016-04-15修订日期：2016-06-28 |
| 基金项目:国家自然科学基金（81303111）. |
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| Correlation analysis of plasma tryptase and blood glucose in patients with diabetic cardiomyopathy |
| LI Na1,ZHENG Xue-yang2,YUE Wen-heng1,HUANG Zhi-gang1* |
(1. Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;
2. Department of Organ Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Objective To observe the expression of clasmatoblast-secreted tryptase in patients with diabetic cardiomyopathy (DCM) and its relationship with fasting blood glucose. Methods Patients with DCM (DCM group, n=32) or ischemic cardiomyopathy (ICM group, n=26) and age-matched healthy volunteers (healthy control group, n=20) were recruited from Changzheng Hospital of Second Military Medical University between August 2012 and March 2013. The clinical characteristics of the participants were collected and the biochemical indices including fasting blood-glucose were detected. ELISA detection reagent kit was used for detecting serum tryptase level in each group. Pearson analysis was used to analyze the correlation between plasma tryptase level and fasting glucose. Results The general clinical characteristics and the fasting blood glucose were not significantly different between the three groups. The plasma tryptase levels in DCM group and ICM group were significantly higher than that in the healthy control group ([7.19±0.62] μg/L,[6.81±0.94] μg/L vs[2.37±0.56] μg/L, P<0.01). DCM group had higher serum tryptase level than ICM group, but with no significant difference. Pearson analysis showed that the plasma tryptase level was positively correlated with fasting blood glucose level (r=0.637, P<0.01). Conclusion The plasma tryptase level is increased in patients with DCM, and it is positively correlated with the fasting blood glucose in all the participants of three groups. |
| Key words: diabetes comolications cardiomyopathies tryptases mast cells cardiac remodeling |
