| 摘要: |
| 目的 评价外用糖皮质激素对老年性干皮症患者皮肤屏障的影响。方法 32例老年性干皮症患者一侧前臂外用0.1%氢化可的松乳膏（实验组），每日1次，持续8周，于第0、2、4、8周进行随访评价，并以用药前后另一侧手臂作为对照（对照组）。皮肤屏障功能评价内容包括检测角质层含水量及经表皮水分丢失（TEWL）值。结果 实验后2周，实验组角质层含水量最高，而TEWL值最低。实验后8周，实验组角质层含水量高于对照组（P<0.01），且TEWL值低于对照组（P<0.01）。结论 外用糖皮质激素对于老年性干皮症患者用药8周时，未观察到皮肤屏障功能破坏；用药2周时对皮肤屏障功能有暂时改善作用。 |
| 关键词: 皮肤屏障 老年性干皮症 糖皮质激素类 |
| DOI：10.16781/j.0258-879x.2016.11.1437 |
| 投稿时间：2016-04-20修订日期：2016-10-22 |
| 基金项目:上海市卫生局科研资助项目（20124155）. |
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| Effect of topical glucocorticoid on skin barrier function of patients with senile xerosis |
| ZHOU Jing,TAN Yi-mei,GAO Yun-lu,YUAN Xiao-hai* |
(Department of Dermatology, Shanghai Dermatology Hospital, Shanghai 200050, China
*Corresponding author.) |
| Abstract: |
| Objective To evaluate the effect of topical glucocorticoid on skin barrier function of patients with senile xerosis. Methods A total of 32 patients were treated with 0.1% topical hydrocortisone cream on one side of the forearms (topical hydrocortisone group), once a day for 8 weeks, and the other forearms were taken as control (control group). Skin barrier function was evaluated at 0, 2, 4 and 8 weeks after experiment using Corneometer and Tewameter. Results The water content of stratum corneum in the topical hydrocortisone group peaked at 2 weeks, while the transepidemal water loss (TEWL) value was the lowest. Compared with the control group, topical hydrocortisone significantly increased the water content of the stratum corneum (P<0.01) and decreased the TEWL value of stratum corneum (P<0.01) after an 8-week treatment. Conclusion The application of topical glucocorticoid in patients with senile xerosis results in no impairment of skin barrier function after an 8-week treatment, and it can temporarily improve the skin barrier function after 2-week treatment. |
| Key words: skin barrier senile xerosis glucocorticoids |
