| 摘要: |
| 目的 研究强直性脊柱炎（ankylosing spondylitis，AS）患者的饮食习惯与健康人群的差异，探讨饮食这一环境因素在AS发病中的作用。方法 对2014年7月到2015年4月在我科就诊的123例AS患者及年龄、性别匹配的120例健康志愿者进行饮食习惯的现况调查，采用单因素及多因素分析比较AS患者和健康对照人群饮食习惯的差异。根据Bath强直性脊柱炎病情活动指数（BASDAI）将AS患者分为病情活动组（BASDAI>4分）和病情无活动组（BASDAI≤4分），研究病情活动与饮食习惯的关系；根据HLA-B27的表达将患者分为HLA-B27阳性组和HLA-B27阴性组，研究饮食和HLA-B27的交互作用对AS发病的影响。结果 AS患者和健康对照人群之间在饮食口味倾向、主食结构、平均每天高胆固醇食物、每天豆类制品、是否吸烟、饮酒频率等饮食习惯上差异存在统计学意义（P<0.05）。多因素分析发现嗜辣口味、每天适量豆制品摄入、适量饮酒是AS发病的保护因素，每天吸烟是AS发病的独立危险因素（P<0.05）。AS病情活动与饮食习惯无关。HLA-B27阳性的患者在饮食口味倾向、豆制品的摄入、吸烟、饮酒等方面与健康对照人群差异有统计学意义（P<0.05，P<0.01）。结论 饮食结构不同可能是AS发病的重要环境因素之一，HLA-B27与饮食习惯对AS发病的影响可能存在交互作用。 |
| 关键词: 强直性脊柱炎 饮食习惯 抗炎饮食 HLA-B27 |
| DOI：10.16781/j.0258-879x.2016.12.1453 |
| 投稿时间：2016-05-29修订日期：2016-10-14 |
| 基金项目: |
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| Investigation of eating habits of patients with ankylosing spondylitis |
| LI Ting△,YIN Jian△,TANG Yu-shuang,ZHAO Juan,WU Xin,XU Hu-ji* |
(Department of Rheumatology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
△Co-first authors.
* Corresponding author) |
| Abstract: |
| Objective To study the difference of eating habits between patients with ankylosing spondylitis (AS) and the healthy controls, and to explore the role of diet as an environmental factor in the pathogenesis of AS. Methods A total of 123 AS patients and 120 matched healthy volunteers were enrolled in the present study from Jul. 2014 to Apr. 2015. The single factor and multivariate analysis were used to compare the differences in eating habits between the patients with AS and the healthy volunteers. According to the Bath ankylosing spondylitis disease activity index (BASDAI), AS patients were divided into active disease group (BASDAI> 4 points) and non-active disease group (BASDAI≤4 points), and the relationship between disease activity and eating habit was studied. The patients were also divided into HLA-B27 positive group and HLA-B27 negative group to study the effects of diet and HLA-B27 interaction on the incidence of AS. Results There were significant differences between the AS patients and the healthy volunteers in eating taste tendency, staple food structure, average daily high cholesterol food, daily soy products, and smoking and drinking frequency(P<0.05). Multivariate analysis showed that spicy taste, moderate daily intake of soy products and moderate drinking were the protective factors for AS, and smoking was an independent risk factor for AS (P<0.05). The disease activity of AS was not related to the eating habits. There were significant differences between HLA-B27 positive patients and the healthy volunteers in eating taste tendency, soy intake, smoking and alcohol consumption(P<0.05, P<0.01). Conclusion The dietary components may be an important environmental influencing factor of AS. HLA-B27 may interact with eating habits in their influence on the pathogenesis of AS. |
| Key words: ankylosing spondylitis food habits anti-inflammatory diet HLA-B27 |
