| 摘要: |
| 胆汁酸（bile acid， BA）作为胆汁的成分之一，参与脂肪消化吸收和胆固醇代谢。近年研究发现，胆汁酸还是一种信号分子，不仅可以与法尼酯衍生物X受体（farnesoid X receptor， FXR）、G 蛋白偶联胆汁酸受体（G protein coupled bile acid receptor 5，TGR5）等结合调节自身代谢，还在糖尿病、肥胖、非酒精性脂肪肝病及其他代谢性疾病中发挥重要作用，因此，阐明其作用机制将为诊治代谢性疾病提供理论依据。本文就胆汁酸在糖脂代谢疾病中的研究进展作一综述。 |
| 关键词: 胆汁酸类和盐类 2型糖尿病 减重手术 非酒精性脂肪肝 法尼酯衍生物X受体 G蛋白偶联的胆汁酸受体 |
| DOI：10.16781/j.0258-879x.2017.06.0780 |
| 投稿时间：2016-11-15修订日期：2017-02-22 |
| 基金项目:长海医院探索项目（CH125541900） |
|
| Bile acid in glucolipid metabolic diseases: an update |
| HE Yi-fei,WANG Qi-jin* |
(Department of Endocrinology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Bile acids, as one of the constituents of bile, can promote the digestion and absorption of fat and cholesterol metabolism. Studies find that bile acid is a signal molecule that not only combines with nuclear hormone receptors such as farnesoid X receptor, and G protein coupled bile acid receptor 5, to regulate their own metabolism, but also plays an important role in diabetes, obesity, non-alcoholic fatty liver disease and other metabolic diseases. The research on its mechanism will provide a solid theoretical basis for the diagnosis and treatment of metabolic diseases. In this review, we summarized the research progress of bile acids in glucolipid metabolic diseases. |
| Key words: bile acids and salts type 2 diabetes mellitus bariatric surgery nonalcoholic fatty liver disease farnesoid X receptor G-protein coupled bile acid receptor |
