| 摘要: |
| 前列腺癌起病隐匿，发现时多为晚期且治疗困难，亟需研发更有效的前列腺癌诊治手段。外泌体是由多种活细胞分泌的直径为30~100 nm的细胞外囊泡。在肿瘤患者的多种体液中均能检测到肿瘤相关外泌体，其在肿瘤的发生、侵袭、转移和耐药性中发挥了重要作用。研究发现，外泌体应用于肿瘤治疗时表现出能穿过天然屏障、细胞靶向性、循环系统中可稳定存在等优势，表明外泌体在前列腺癌治疗方面具有巨大潜力。本文综述了外泌体的主要特点和功能及其在前列腺癌诊疗方面的研究进展。 |
| 关键词: 外泌体 前列腺肿瘤 诊断 治疗学 |
| DOI：10.16781/j.0258-879x.2017.01.0086 |
| 投稿时间：2016-10-14修订日期：2016-12-22 |
| 基金项目:国家自然科学基金重点项目（81430058）. |
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| Exosomes in diagnosis and treatment of prostate cancer: recent progress |
| PENG Guang,WANG Chao,YANG Bo,SUN Ying-hao* |
(Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Prostate cancer is a malignant tumor with insidious onset, and it usually gets into a terminal stage when discovered and has limited therapy measures. Hence, novel and more effective diagnostic and therapeutic approaches of prostate cancer are greatly needed. Exosomes are one subtype of extracellular vesicles (30-100 nm) secreted by various living cells. Tumor-associated exosomes have been identified in various body fluids from cancer patients and playing important roles in promoting tumor growth, invasion, metastasis and drug resistance. Furthermore, exosomes have multiple advantages when applied in cancer therapy, including the ability to overcome natural barriers, intrinsic cell targeting properties and stability in the circulation, which implies an enormous potential for treatment of prostate cancer. In this review, we summarized the characteristics and functions of exosomes, and discussed the potential value of exosomes as biomarkers and therapeutic tools for prostate cancer. |
| Key words: exosomes prostatic neoplasms diagnosis therapeutics |
