| 摘要: |
| 肝干细胞是具有自我更新能力和分化为成熟肝细胞与胆管上皮细胞的双向分化潜能的原始细胞。肝干细胞不仅参与了肝脏的稳态维持、损伤修复和肝再生，而且在肝脏疾病的细胞治疗、人工生物肝及肝导向基因治疗中有着巨大的应用潜能。本文对几种主要类型的肝干细胞及它们的来源、分子标志物等进行了综述。 |
| 关键词: 干细胞 胚胎肝干细胞 成体肝干细胞 肝再生 |
| DOI：10.16781/j.0258-879x.2017.04.0493 |
| 投稿时间：2017-03-15修订日期：2017-04-10 |
| 基金项目:国家自然科学基金（31401166），国家重点基础研究发展计划（"973计划"，2010CB945602）. |
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| Research progress on liver stem cells |
| LU Lian,YU Bing,HU Yi-ping* |
(Department of Cell Biology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Liver stem cells are primitive cells with self-renewing capacity and bidirectional differentiation potential to differentiate into mature hepatocytes or biliary epithelial cells. Liver stem cells not only play roles in the homeostasis maintenance, injury repair and regeneration of liver, but also have huge potential applications in cell therapy of liver diseases, construction of bioartificial liver and liver-oriented gene therapy. In this review, we summarized the major types of liver stem cells, as well as their origins and molecular markers. |
| Key words: stem cells embryonic liver stem cells adult liver stem cells liver regeneration |
