| 摘要: |
| 氧化应激损伤是导致疾病的一个重要因素。间充质干细胞来源外泌体（MSC-exo）含有多种蛋白质、脂质、编码RNA及非编码RNA，可通过多种途径减轻机体的氧化应激损伤，促进受损的组织细胞修复再生，因此MSC-exo在氧化应激所致疾病的治疗中有巨大的发展潜力。本文对MSC-exo在减轻氧化应激导致的心血管损伤、肺组织损伤、肾脏损伤、肝细胞损伤等方面的研究进展作一综述。 |
| 关键词: 间充质干细胞 外泌体 氧化性应激 损伤修复 |
| DOI：10.16781/j.0258-879x.2018.07.0716 |
| 投稿时间：2018-02-09修订日期：2018-06-21 |
| 基金项目:国家自然科学基金面上项目（81670741），国家自然科学基金青年项目（81701199），长海医院“1255”学科建设计划科研创新探索项目（CH125541900）. |
|
| Research progress of mesenchymal stem cell-derived exosomes in oxidative stress injury |
| ZHAI Xiao1,WANG Yi-ran2,ZHU Ming-xiang2,WANG Qi-jin3* |
(1. Department of Spine Surgery, Changhai Hospital, Navy Medical University(Second Military Medical University), Shanghai 200433, China;
2. The Third Student Team, College of Basic Medical Sciences, Navy Medical University(Second Military Medical University), Shanghai 200433, China;
3. Department of Endocrinology, Changhai Hospital, Navy Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Oxidative stress damage is known to be a major factor leading to many diseases. Mesenchymal stem cell-derived exosomes (MSC-exos) are enriched with various proteins, lipids, coding RNAs and non-coding RNAs, and alleviate oxidative stress damage and stimulate the regeneration response of damaged tissues and cells. MSC-exos hold a great potential for the treatment of diseases caused by oxidative stress. In this review, we summarized the research progress of MSC-exos in cardiovascular injury, lung injury, kidney injury and liver cell injury caused by oxidative stress. |
| Key words: mesenchymal stem cells exosomes oxdative stress damage repair |
