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| 原发性失眠症功能磁共振成像研究进展 |
| 何静文1,魏燕燕2,苏彤1,潘霄1,崔轶1,李自强3,唐云翔1* |
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(1. 海军军医大学(第二军医大学)心理与精神卫生学系医学心理学教研室, 上海 200433;
2. 上海市精神卫生中心脑电影像室, 上海 200030;
3. 解放军91912部队保障部, 宁德 352103
*通信作者) |
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| 摘要: |
| 原发性失眠症（PI）是一种常见的睡眠障碍，会影响人的认知、情绪调节等功能。多项研究表明PI涉及广泛的脑区异常。近年来，功能磁共振成像技术结合不同的分析方法被广泛应用于PI的研究，它可以客观、间接地分析大脑功能活动的改变，有助于阐明PI的神经病理学机制，并为疾病的早期诊断提供可靠的客观依据。本文综述了近年来任务态功能磁共振成像、静息态功能磁共振成像等技术和功能连接分析方法在PI中的应用。 |
| 关键词: 原发性失眠症 任务态功能磁共振成像 静息态功能磁共振成像 功能连接 |
| DOI：10.16781/j.0258-879x.2018.10.1143 |
| 投稿时间：2017-09-19修订日期：2017-12-07 |
| 基金项目:国家自然科学基金（81372122），军队"十二五"重大项目分题（AWS13J003，AWS12J003），全军军事科研"十二五"计划课题（13QJ003-005），全军心理卫生应用型科研课题重点项目（12XLZ109）. |
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| Research advances of functional magnetic resonance imaging in patients with primary insomnia |
| HE Jing-wen1,WEI Yan-yan2,SU Tong1,PAN Xiao1,CUI Yi1,LI Zi-qiang3,TANG Yun-xiang1* |
(1. Department of Psychological and Mental Health, Faculty of Mental Health and Psychology, Navy Medical University(Second Military Medical University), Shanghai 200433, China;
2. Department of Electronic Encephalography Source Imaging, Shanghai Mental Health Center, Shanghai 200030, China;
3. Department of Security, No. 91912 Troop of PLA, Ningde 352103, Fujian, China
*Corresponding author) |
| Abstract: |
| Primary insomnia (PI), a prevalent sleep disorder, has been associated with cognitive deficits and emotional disorders. Several studies have shown that PI involves a wide range of brain abnormalities. In recent years, functional magnetic resonance imaging techniques combined with different analysis methods are widely applied in the study of PI. It can objectively and indirectly analyze the changes in brain functional activities, help to elucidate the neuropathological mechanisms of PI, and provide reliable objective basis for the early diagnosis of disease. In this paper, we reviewed the application of task state functional magnetic resonance imaging, resting-state functional magnetic resonance imaging and function connectivity in patients with PI. |
| Key words: primary insomnia task-based functional magnetic resonance imaging resting-state functional magnetic resonance imaging functional connectivity |
