| 摘要: |
| 外泌体是细胞多泡内体与质膜融合时释放产生的微小囊泡。近些年外泌体的研究逐渐受到重视，然而大多数研究都集中在外泌体中信使RNA（mRNA）、微RNA（microRNA）和长链基因间非编码RNA（lincRNA）等的功能作用上，而对其所含糖蛋白的研究报道较少。近年研究发现，许多疾病包括肿瘤在内，都与外泌体糖蛋白关系密切。本文针对外泌体糖蛋白在肿瘤等疾病中的作用作一综述。 |
| 关键词: 外泌体 糖蛋白类 肿瘤 肝疾病 阿尔茨海默病 |
| DOI：10.16781/j.0258-879x.2018.07.0711 |
| 投稿时间：2017-11-13修订日期：2017-12-31 |
| 基金项目:国家自然科学基金（81670565）. |
|
| Role of exosome glycoprotein in diseases: recent progress |
| ZENG Tao,LI Li,ZHAO Yun-peng,WANG Yue* |
(Department of Histology and Embryology, College of Basic Medical Sciences, Navy Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Exosomes are the microvesicles released from cells during fusion of multivesicular endosomes with plasma membrane. In recent years, most studies have focused on the function of some molecules contained in exosomes, such as messenger RNA (mRNA), microRNA and long intergenic non-coding RNA (lincRNA). The studies about glycoproteins contained in exosomes are rarely reported. Recent researches have shown that many diseases, including tumor, are closely associated with glycoproteins contained in exosomes. In this review, we described the role of exosome glycoproteins in tumors and other diseases. |
| Key words: exosomes glycoproteins neoplasms liver diseases Alzheimer disease |
