| 摘要: |
| 抑郁症是一种临床常见精神疾病，对人类健康造成极大威胁。近年研究发现，发挥免疫效应的小胶质细胞和抑郁症的发生密切相关。小胶质细胞可以通过多种炎症机制和非炎症机制诱导抑郁症的发生，深入研究小胶质细胞在抑郁症发病过程中的作用及其机制，对探寻新的抑郁症治疗靶点、研发新型抗抑郁药有重要意义。 |
| 关键词: 抑郁症 小胶质细胞 炎症 神经元可塑性 色氨酸代谢途径 |
| DOI：10.16781/j.0258-879x.2018.07.0780 |
| 投稿时间：2018-01-03修订日期：2018-05-11 |
| 基金项目:国家自然科学基金（81571169）. |
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| Role of microglia in pathogenesis of depression: an update |
| LI Jia-mei,JIANG Chun-lei* |
(Laboratory of Stress Medicine, Faculty of Psychology and Mental Health, Navy Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Depression is a common clinical mental disease and has posed a serious threat to human health. Recent studies have found that immune-effecting microglia is closely related to the occurrence of depression. Microglia induces depression through a variety of inflammatory and non-inflammatory mechanisms. It is of great significance to study the role of microglia in the occurrence of depression, which can help to explore new targets of depression treatment and novel antidepressants. |
| Key words: depression microglia inflammation neuronal plasticity tryptophan metabolic pathway |
