| 摘要: |
| 黄病毒属虫媒病毒多为新发突发传染病的病原体，已在全球引发多起突发公共卫生事件，对人类健康构成严重威胁。减毒疫苗是黄病毒属虫媒病毒最有效的疫苗类型，通过连续细胞传代筛选的黄热病病毒和乙型脑炎病毒减毒疫苗对预防这两种黄病毒感染发挥了重要作用。近年来，利用病毒反向遗传学技术对黄病毒基因组进行定点改造以获得减毒表型，在黄病毒属虫媒病毒疫苗研制中取得重要进展。本文就黄病毒属虫媒病毒减毒疫苗的历史和研究现状进行综述。 |
| 关键词: 黄病毒属 病毒疫苗 减毒疫苗 感染性克隆 |
| DOI：10.16781/j.0258-879x.2019.02.0196 |
| 投稿时间：2018-09-06修订日期：2019-01-24 |
| 基金项目:国家重点研发计划（2016YFC1200401），国家重大科技专项（2017ZX10304403-003）. |
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| Attenuated vaccines of Flavivirus genus arborvirus: an update |
| XU Zheng-hao,ZHAO Ping,QI Zhong-tian* |
(Department of Biodefense, Faculty of Naval Medicine, Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| As a pathogen causing many infectious diseases, Flavivirus genus arborvirus has caused public health emergencies worldwide and posed a serious threat to human health. Attenuated vaccine is the most effective vaccine type against Flavivirus genus arborvirus. The attenuated vaccines against yellow fever virus and Japanese encephalitis virus obtained by consecutive cell passages play an important role in preventing viral infections. Recently, reverse genetics technique has been used to modify the flavivirus genome to obtain the attenuated phenotype, and this technique has made significant progress in the development of Flavivirus genus arbovirus vaccines. This review summarizes the history and the current status of attenuated vaccine of Flavivirus genus arborvirus. |
| Key words: flavivirus viral vaccines attenuated vaccines infectious clone |
