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| 钛金属内植物表面抗菌肽的应用进展 |
| 赫荣智1,迪力夏提·安外尔1,徐凯航1,秦升1,章浩1,纪方2* |
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(1. 海军军医大学(第二军医大学)长海医院创伤骨科, 上海 200433;
2. 上海交通大学医学院附属第九人民医院骨科, 上海 200011
*通信作者) |
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| 摘要: |
| 抗菌肽广泛存在于多种生物体内，是生物体非特异性免疫功能的重要组成部分。其可以保护机体免受细菌、真菌、寄生虫和病毒等病原体的侵袭，还具有介导催化、凋亡、免疫调节活性、促进伤口愈合和促成骨等作用，是钛金属内植物表面抗菌涂层研究的热点，具有良好的应用前景。本文就应用于钛金属内植物表面的抗菌肽的抗菌机制、加载方式和应用现状等进行综述。 |
| 关键词: 钛 假体和植入物 抗菌肽 抗菌机制 加载方式 抗菌活力 |
| DOI：10.16781/j.0258-879x.2020.09.1021 |
| 投稿时间：2019-12-26修订日期：2020-07-17 |
| 基金项目:军事医学创新工程（16CXZ010）． |
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| Application of antimicrobial peptides on titanium implant surface: recent progress |
| HE Rong-zhi1,Dilixiati Anwaier1,XU Kai-hang1,QIN Sheng1,ZHANG Hao1,JI Fang2* |
(1. Department of Orthopaedic Trauma, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China;
2. Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
*Corresponding author) |
| Abstract: |
| Antimicrobial peptides (AMPs) distribute widely in many organisms. As an important part of the non-specific immune functions of organisms, AMPs can not only protect the body from bacteria, fungi, parasites, viruses, and other pathogens, but also have the functions of mediating catalysis, apoptosis, immune regulatory activity, accelerating wound healing and osteogenetic effects. AMPs have become a research focus for antimicrobial coating on titanium implant surface and have shown a promising prospect. In this paper, we reviewed the antimicrobial mechanism, loading method, and application status of AMPs applied on titanium implant surface. |
| Key words: titanium prostheses and implants antimicrobial peptides antimicrobial mechanism loading method antimicrobial activity |
