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| NLRX1的生理功能及在呼吸系统疾病中的研究进展 |
| 肖江1,朱成杰2,商艳1,3*,白冲1 |
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(1. 海军军医大学(第二军医大学)长海医院呼吸与危重症医学科, 上海 200433;
2. 中国人民解放军 94804部队卫生队, 上海 200434;
3. 海军军医大学(第二军医大学)长海医院全科医学科, 上海 200433
*通信作者) |
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| 摘要: |
| 核苷酸结合寡聚化结构域（NOD）和富含亮氨酸重复序列的家族蛋白X1（NLRX1）是NOD样受体（NLR）家族的一员，是免疫系统的重要调节因子。研究表明，NLRX1能够调控NF-κB信号和Ⅰ型干扰素生成，调节活性氧的产生，参与自噬、细胞死亡和固有免疫反应，并影响JNK和MAPK途径。NLRX1与呼吸道病毒感染性疾病、慢性阻塞性肺疾病、阻塞型睡眠呼吸暂停低通气综合征和肺部肿瘤等疾病的发生、发展密切相关。因此，了解NLRX1在这些疾病中的作用及机制具有十分重要的意义。 |
| 关键词: 富含亮氨酸重复序列的家族蛋白X1 活性氧 炎症 核因子κB 呼吸系统疾病 |
| DOI：10.16781/j.0258-879x.2021.06.0664 |
| 投稿时间：2020-02-25修订日期：2020-03-31 |
| 基金项目:国家自然科学基金（81570020），海军军医大学（第二军医大学）长海医院科研基金（2019SLZ002，2019YXK018），上海市自然科学基金（21ZR1479200）. |
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| Physiological function of NLRX1 and its research progress in respiratory diseases |
| XIAO Jiang1,ZHU Cheng-jie2,SHANG Yan1,3*,BAI Chong1 |
(1. Department of Respiratory and Critical Care Medicine, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. Health Service Team, No. 94804 Troop of PLA, Shanghai 200434, China;
3. Department of General Practice, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Nucleotide binding oligomerization domain (NOD) and leucine-rich-repeat-containing protein X1 (NLRX1), a member of the NOD-like receptor (NLR) family, is an important regulator of the immune system. Studies have shown that NLRX1 could regulate nuclear factor kappa B signaling and typeⅠinterferon generation, regulate reactive oxygen species production, participate in autophagy, cell death and innate immunity response, and affect c-Jun N-terminal kinase and mitogen-activated protein kinase pathways. NLRX1 is closely related to the development and progression of respiratory virus infection, chronic obstructive pulmonary disease, obstructive sleep apnea hypopnea syndrome and lung tumors. Therefore, it is of great significance to understand the role and mechanism of NLRX1 in these diseases. |
| Key words: leucine-rich-repeat-containing protein X1 reactive oxygen species inflammation nuclear factor kappa B respiratory diseases |
