| 摘要: |
| 细胞因子风暴是一种失控的过度免疫应答，是冠状病毒肺炎的重要发病机制。病毒劫持机体的免疫系统，导致免疫调节的负反馈丧失、多种细胞因子异常升高，损害了肺泡弥散功能并造成多器官功能障碍。靶向冠状病毒细胞因子风暴的特异性治疗研究，如粒细胞集落刺激因子、托珠单抗、卡莫他特、血液净化治疗等已取得系列成果，其可能是缓解新型冠状病毒肺炎（COVID-19）疫情的有效手段。但COVID-19具有独特的病理特征，上述治疗的研究成果仍需进一步临床试验来验证。本文就冠状病毒肺炎细胞因子风暴及免疫调控治疗进展进行综述。 |
| 关键词: 冠状病毒感染 肺炎 细胞因子风暴 粒细胞集落刺激因子 托珠单抗 卡莫他特 |
| DOI：10.16781/j.0258-879x.2020.08.0818 |
| 投稿时间：2020-03-03修订日期：2020-06-21 |
| 基金项目:国家自然科学基金（81671939，81871579）． |
|
| Cytokine storm and immunoregulatory therapy of coronavirus pneumonia |
| WANG Ting1,JIANG Zheng-yu2,WAN Xiao-jian1,3*,BIAN Jin-jun1* |
(1. Department of Anesthesiology, Changhai Hospital, Naval Medical University(Second Military Medical University), Shanghai 200433, China;
2. Department of Anesthesiology, Naval Special Medical Center, Naval Medical University(Second Military Medical University), Shanghai 200052, China;
3. Department of Infectious Diseases(Ⅱ), Huoshenshan Hospital, Wuhan 430100, Hubei, China
*Corresponding authors) |
| Abstract: |
| Cytokine storm, a runaway overwhelming immune response, plays an important part in the pathogenesis of coronavirus. The virus hijacks the immune system, resulting in a loss of negative feedback on the immune regulation and an overproduction of inflammatory cytokines, which subsequently impairs the pulmonary diffusion function and leads to multi-organ dysfunction. A series of progresses have been achieved in studies targeting the coronavirus cytokine storm, such as granulocyte colony-stimulating factor, tocilizumab, camostat mesylate, and blood purification treatment, which may provide effective ways to alleviate the coronavirus disease 2019 (COVID-19) epidemic. Nevertheless, further clinical verifications of the above research findings are requested due to the unique pathology of COVID-19. This paper reviews the advances in cytokine storm and immunoregulatory therapy of coronavirus pneumonia. |
| Key words: coronavirus infections pneumonia cytokine storm granulocyte colony-stimulating factor tocilizumab camostat mesylate |
