| 摘要: |
| 目的 测定冠状动脉慢血流（CSF）患者血清内皮型一氧化氮合酶（eNOS）水平，评价其与CSF的相关性。方法 选择2018年1月至2019年12月在我院行冠状动脉造影检查确诊的CSF患者36例作为研究对象，以同期入院行冠状动脉造影检查无CSF现象的患者36例作为对照。应用心肌梗死溶栓血流帧数（TFC）评价冠状动脉血流速度，ELISA法测定血清eNOS含量，并分析两者相关性。结果 CSF组各支血管（左前降支、左回旋支、右冠状动脉）的TFC和3支血管的平均TFC（mTFC）均高于对照组（P均<0.001），CSF组血清eNOS水平低于对照组［（46.40±5.57）ng/L vs （59.91±8.75）ng/L，P<0.001］。Pearson相关性分析显示，CSF患者的mTFC与血清eNOS水平呈负相关（r＝－0.658，P<0.001）。结论 CSF患者血清eNOS水平下降，且与冠状动脉血流速度呈负相关关系，eNOS表达下降可能是CSF的重要病因。 |
| 关键词: 冠状动脉慢血流 内皮型一氧化氮合酶 心肌梗死溶栓血流帧数 相关性 |
| DOI：10.16781/j.CN31-2187/R.20200690 |
| 投稿时间：2020-05-10修订日期：2020-11-01 |
| 基金项目:国家自然科学基金（82104588），海军军医大学（第二军医大学）第二附属医院金字塔人才工程（YQ662）. |
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| Correlation between serum endothelial nitric oxide synthase level and coronary slow flow |
| ZHAO Jian,ZHANG Yan-da,LIANG Chun* |
(Department of Cardiovasology, The Second Affiliated Hospital of Naval Medical University(Second Military Medical University), Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Objective To determine the level of serum endothelial nitric oxide synthase (eNOS) in patients with coronary slow flow (CSF) and evaluate its correlation with CSF. Methods Thirty-six patients with CSF diagnosed by coronary angiography in our hospital from Jan. 2018 to Dec. 2019 were enrolled (CSF group), and 36 patients without CSF phenomenon who underwent coronary angiography during the same period were enrolled as control group. The coronary flow velocity was evaluated by thrombolysis in myocardial infarction frame count (TFC), serum eNOS level was measured by enzyme-linked immunosorbent assay, and the correlation between them were analyzed. Results TFC and mean TFC (mTFC) of all coronary arteries (left anterior descending, left circumflex, and right coronary artery) in the CSF group were significantly higher than those in the control group (all P<0.001), and the serum eNOS level in the CSF group was significantly lower than that in the control group ([46.40±5.57] ng/L vs[59.91±8.75] ng/L, P<0.001). Pearson correlation analysis showed that there was a negative correlation between mTFC and serum eNOS level (r=-0.658, P<0.001). Conclusion Serum eNOS level of CSF patients is significantly decreased, and it is negatively correlated with coronary flow velocity. Low eNOS expression may be an important cause of CSF. |
| Key words: coronary slow flow endothelial nitric oxide synthase thrombolysis in myocardial infarction frame count correlation |
