| 摘要: |
| 黄热病毒（YFV）属于黄病毒科黄病毒属，是一类有包膜的单正链RNA病毒。尽管疫苗能有效预防YFV感染，但普及率较低，加之缺乏有效抗病毒药物，YFV仍周期性暴发。YFV基因组编码的病毒蛋白在其感染的各个阶段均发挥重要作用，因此研发靶向YFV蛋白的治疗药物是提高黄热病治疗效果、降低病死率的有效措施。本文简要介绍了YFV基因组编码的病毒蛋白的结构和功能，并综述了针对这些靶点研发抗YFV药物的进展和发展前景，为防治YFV感染提供参考。 |
| 关键词: 黄热病毒 病毒蛋白 抗病毒药 靶向药物 |
| DOI：10.16781/j.0258-879x.2021.07.0783 |
| 投稿时间：2020-07-09修订日期：2020-12-18 |
| 基金项目:国家自然科学基金青年科学基金（31700147），国家科技重大专项重大传染病防治课题（2017ZX10304403-003）. |
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| Antiviral drugs targeting yellow fever virus-encoded proteins: research progress |
| WU Bing-an1,PENG Ke2,FENG Qi-fan2,QI Zhong-tian1,QIAN Xi-jing1* |
(1. Department of Biomedical Defense, Faculty of Naval Medicine, Naval Medical University (Second Military Medical University), Shanghai 200433, China;
2. College of Basic Medical Sciences, Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Yellow fever virus (YFV) is a member of the Flavivirus genus within the Flaviviridae family. It is an enveloped single-stranded positive-sense RNA virus. Although the vaccine can effectively prevent YFV infection, the low coverage of vaccination and lack of effective antiviral drugs result in frequent outbreaks of YFV. YFV genome encoded proteins play important roles in basically all steps of viral infection. Therefore, the development of therapeutic drugs targeting YFV proteins is an effective measure to improve the therapeutic effect and reduce the mortality of this infectious disease. In this review, we briefly introduce the structure and function of the YFV genome encoded proteins, and summarize the research progresses and prospects of anti-YFV drugs targeting these proteins, so as to provide references for prevention and treatment of YFV infection. |
| Key words: yellow fever virus viral protein antiviral drugs targeted drugs |
