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| 创伤后应激障碍的脑功能磁共振成像研究进展 |
| 龚昕妍1,贾砚璞2,3,刘伟志2,3* |
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(1. 中国人民解放军联勤保障部队904医院医学影像科, 无锡 214008;
2. 海军军医大学(第二军医大学)心理系基础心理学教研室, 上海 200433;
3. 海军军医大学(第二军医大学)心理系创伤后应激障碍防护实验室, 上海 200433
*通信作者) |
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| 摘要: |
| 创伤后应激障碍（PTSD）是由异常威胁性或灾难性事件导致的一类心理障碍，是21世纪迫切需要关注的公共卫生事件之一。探讨PTSD潜在的脑机制可为PTSD的早期干预、心理护理及追踪治疗提供理论基础。现有的研究从静息态和任务态两个方面对PTSD脑功能磁共振成像进行分析，结果表明PTSD患者的杏仁核反应增强、海马体积变小、前扣带回及内侧前额叶皮质反应减弱。未来的研究应关注控制组的选择，尤其是有无共病障碍的PTSD群体。 |
| 关键词: 创伤后应激障碍 功能磁共振成像 静息态 任务态 |
| DOI：10.16781/j.0258-879x.2020.08.0891 |
| 投稿时间：2020-07-19修订日期：2020-08-05 |
| 基金项目:未来战争医学防护课题（19WLMS-15），军队“十三五”双重建设项目（201944815），海军重点课程建设项目（20180925），海军院校学科专业重点项目：精神医学（2017）. |
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| Brain functional magnetic resonance imaging of post-traumatic stress disorder: recent progress |
| GONG Xin-yan1,JIA Yan-pu2,3,LIU Wei-zhi2,3* |
(1. Department of Medical Imaging, No. 904 Hospital of Logistic Support Forces of PLA, Wuxi 214008, Jiangsu, China;
2. Department of Basic Psychology, Faculty of Psychology, Naval Medical University(Second Military Medical University), Shanghai 200433, China;
3. Lab for Post-Traumatic Stress Disorder, Faculty of Psychology, Naval Medical University(Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Post-traumatic stress disorder (PTSD) is a kind of psychological disorder caused by unusual threatening or catastrophic events, and it is one of the urgent public health events in the 21st century, which deserves more attention. Exploration of the underlying brain mechanisms of PTSD can provide theoretical basis for the early intervention, psychological nursing and follow-up treatment of PTSD. Current studies have analyzed PTSD brain functional magnetic resonance imaging at resting state and task state. The results showed that the amygdala response was enhanced in PTSD patients, and their hippocampal volume was reduced with decreased response of anterior cingulate cortex and medial prefrontal cortex. Future studies should attach greater importance to the selection of control group, with special focus on the presence of comorbidity. |
| Key words: post-traumatic stress disorder functional magnetic resonance imaging resting state task state |
