| 摘要: |
| 椎间盘退变是造成下腰痛的重要原因之一。尽管外科干预能够取得一定的症状缓解效果，但是如何早期预防和缓解椎间盘退变仍然是目前研究的重点内容，因此探究椎间盘退变的内在机制尤为重要。人体作为一个完整的生态体，其他系统直接或间接地参与了椎间盘退变的发病。本文从神经、免疫和内分泌系统3个角度对椎间盘退变的机制进行综述，希望为未来椎间盘退变预防和治疗的研究提供新的思路。 |
| 关键词: 椎间盘退行性变 神经系统 免疫系统 内分泌系统 机制 |
| DOI：10.16781/j.0258-879x.2021.06.0670 |
| 投稿时间：2020-09-04修订日期：2020-12-18 |
| 基金项目:国家自然科学基金面上项目（81871828）. |
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| Advances in nerve, immune and endocrine systems involving in intervertebral disc degeneration |
| SUN Kai-qiang,SHI Jian-gang* |
(Department of Spinal Surgery, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai 200003, China
*Corresponding author) |
| Abstract: |
| Intervertebral disc degeneration (IVDD) has been one of the most significant contributors to low back pain. Despite the favorable outcomes resulted from surgical intervention, early prevention and alleviation of IVDD have been a research focus. Therefore, it is particularly important to investigate the potential mechanism of IVDD. Increasing studies have suggested that multiple systems in our body are involved in the process of IVDD directly or indirectly. This article reviews the mechanism of IVDD from the perspectives of nerve, immune and endocrine systems, hoping to provide new insights into the future prevention and treatment of IVDD. |
| Key words: intervertebral disc degeneration nervous system immune system endocrine system mechanism |
