| 摘要: |
| 抑郁症是一种危害全球人类生活质量的精神疾病，具有高患病率、高疾病负担、高致残率等特点。目前有多种针对单胺类神经递质的抗抑郁药物可供使用，然而，约1/3的患者在接受基于多种单胺类药物充分治疗后仍然不能治愈，此类抑郁症在临床上被称为难治性抑郁症。难治性抑郁症的具体病理生理机制尚未明确，但随着抑郁症的炎症机制不断被大众认可，难治性抑郁症的神经炎症也备受关注。本文从炎症的角度对难治性抑郁症的发病机制进行综述，为深入研究其诊断和治疗方法提供思路与方向。 |
| 关键词: 难治性抑郁症 炎症 细胞因子 小胶质细胞 糖皮质激素 |
| DOI：10.16781/j.CN31-2187/R.20201430 |
| 投稿时间：2020-12-01 |
| 基金项目: |
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| Inflammatory mechanism of treatment-resistant depression: research progress |
| HU Ting,LI Jia-mei,JIANG Chun-lei* |
(Department of Stress Medicine, Faculty of Psychology, Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| Depression is a kind of mental illness that endangers the quality of life among human beings all over the world. It has the characteristics of high morbidity, high disease burden, and high disability rate. Despite the availability of several antidepressants targeting monoamine transmitters, nearly a third of patients fail to respond to treatment after adequate treatment based on multiple monoamine therapies. The condition is clinically known as treatment-resistant depression. At present, the specific pathophysiological mechanism of the disease is not clear, but with the increasing recognition of the inflammatory mechanism of depression, the neuroinflammation of treatment-resistant depression has attracted much attention. This paper reviews the pathogenesis of treatment-resistant depression from the perspective of inflammation, so as to provide ideas and directions for further research. |
| Key words: treatment-resistant depression inflammation cytokines microglia glucocorticoids |
