| 摘要: |
| 目前，氧化应激在骨质疏松发病中的地位日益突出。研究发现高水平的活性氧及相关氧化产物的蓄积可打破骨代谢平衡，造成骨质疏松症的发生。近年来，中药及其化学成分通过改善氧化应激防治骨质疏松的研究日益增多，并取得较多进展。本文在对氧化应激与骨质疏松症关系进行总结的基础上，对常见中药及其抗氧化化学成分如黄酮类、多酚类、皂苷类等经由抗氧化应激机制防治骨质疏松症的研究做出简要综述，以期为临床应用、新药研发等提供借鉴。 |
| 关键词: 氧化性应激 骨质疏松 中药 化学成分 抗氧化剂 |
| DOI：10.16781/j.CN31-2187/R.20201547 |
| 投稿时间：2020-12-31修订日期：2021-11-09 |
| 基金项目:国家自然科学基金(82174079,U1603283,82004015),上海市科学技术委员会生物医药领域科技支撑项目(21S21902600). |
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| Application of Chinese materia medica and chemical constituents in osteoporosis based on antioxidant mechanism |
| LAI Li-yong1,XU Sheng-yan2,XIA Tian-shuang2,JIANG Yi-ping2,XIN Hai-liang2* |
| (School of Traditional Chinese Medicine, Naval Medical University (Second Military Medical University), Shanghai 200433, China;Department of Pharmacognosy, School of Pharmacy, Naval Medical University (Second Military Medical University), Shanghai 200433, China;1. School of Traditional Chinese Medicine, Naval Medical University (Second Military Medical University), Shanghai 200433, China) |
| Abstract: |
| At present,oxidative stress plays an increasingly prominent role in the pathogenesis of osteoporosis.It has been found that the accumulation of high levels of reactive oxygen species and related oxidation products can break the balance of bone metabolism and lead to osteoporosis.In recent years,researches of Chinese materia medica and its chemical constituents in preventing and treating osteoporosis by alleviating oxidative stress are growing,and some achievements have been obtained.In this paper,the pathogenesis of osteoporosis mediated by oxidative stress was briefly reviewed by referring to relevant literatures,the researches and applications of Chinese materia medica and its antioxidant chemicals,such as flavonoids,polyphenols and saponins on osteoporosis were also introduced,and it may provide reference for the clinical application and research and development of new drug. |
| Key words: oxidative stress osteoporosis Chinese materia medica chemical constituents antioxidants |
