| 摘要: |
| 近年来，肠道菌群的宏基因组、代谢组学的研究进展迅速，但与肠道免疫细胞的相互作用尚不十分清楚。固有淋巴细胞3群（ILC3）是一类富集于肠黏膜的固有免疫细胞，是抵御肠道微生物感染的重要防线。一方面，肠道菌群及其代谢产物直接或间接地影响ILC3的发育、增殖及功能，在不同的微生物信号的作用下，ILC3表型可以发生转变，其作用亦具有两面性；另一方面，ILC3维护了肠道菌群的共生平衡，并调节了其他免疫细胞对共生菌的反应。本文就ILC3与肠道菌群相互作用的研究进展进行综述。 |
| 关键词: 固有淋巴细胞3群 肠道菌群 胃肠道微生物组 肠道疾病 免疫细胞 |
| DOI：10.16781/j.0258-879x.2021.11.1279 |
| 投稿时间：2021-03-24修订日期：2021-08-26 |
| 基金项目:国家自然科学基金青年科学基金（81700460）. |
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| Interaction between group 3 innate lymphoid cells and intestinal flora: research progress |
| MA Jia-yi,HU Liang-hao* |
(Department of Gastroenterology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai 200433, China
*Corresponding author) |
| Abstract: |
| In recent years, the research on metagenomics and metabonomics of intestinal flora has progressed rapidly, but the interaction with intestinal immune cells remains unclear. Group 3 innate lymphoid cells (ILC3) are a population of innate immune cells enriched in the intestinal mucosa, which is an important defense against intestinal microbial infection. On the one side, intestinal flora and its metabolites can directly or indirectly affect the development, proliferation and function of ILC3, and ILC3 may transform into different phenotypes and play a double-edged-sword role according to different microbial signals; on the other side, ILC3 can maintain the balance of resident microbiota and regulate responses of other immune cells to intestinal commensal bacteria. This article reviews the interaction between ILC3 and intestinal flora. |
| Key words: group 3 innate lymphoid cells intestinal flora gastrointestinal microbiome intestinal disease immune cells |
